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Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor
With a high community transmission rate, SARS-CoV-2 has profoundly exacerbated the shortage of organs. Although the risk of donor-recipient transmission of SARS-CoV-2 is anecdotally low, an organ-specific infection analysis of procured organs from SARS-CoV-2 positive donors has yet to be established...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258928/ https://www.ncbi.nlm.nih.gov/pubmed/35813455 http://dx.doi.org/10.1093/jscr/rjac314 |
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author | Zhang, Jared R Kueht, Michael Lea, A Scott Stevenson, Heather L Gosnell, Joseph Ren, Ping Nielsen, Marisa C Miller, Aaron Mujtaba, Muhammad Fair, Jeffrey |
author_facet | Zhang, Jared R Kueht, Michael Lea, A Scott Stevenson, Heather L Gosnell, Joseph Ren, Ping Nielsen, Marisa C Miller, Aaron Mujtaba, Muhammad Fair, Jeffrey |
author_sort | Zhang, Jared R |
collection | PubMed |
description | With a high community transmission rate, SARS-CoV-2 has profoundly exacerbated the shortage of organs. Although the risk of donor-recipient transmission of SARS-CoV-2 is anecdotally low, an organ-specific infection analysis of procured organs from SARS-CoV-2 positive donors has yet to be established. Using a combination of clinically available and research-only polymerase chain reaction methods, organ preservation fluid and renal parenchymal tissues were tested for SARS-CoV-2 from the kidney of a SARS-CoV-2-positive donor prior to transplantation. The recipient has remained SARS-CoV-2 negative and clinically well, with excellent graft function 120 days post-transplantation. |
format | Online Article Text |
id | pubmed-9258928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-92589282022-07-07 Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor Zhang, Jared R Kueht, Michael Lea, A Scott Stevenson, Heather L Gosnell, Joseph Ren, Ping Nielsen, Marisa C Miller, Aaron Mujtaba, Muhammad Fair, Jeffrey J Surg Case Rep Case Report With a high community transmission rate, SARS-CoV-2 has profoundly exacerbated the shortage of organs. Although the risk of donor-recipient transmission of SARS-CoV-2 is anecdotally low, an organ-specific infection analysis of procured organs from SARS-CoV-2 positive donors has yet to be established. Using a combination of clinically available and research-only polymerase chain reaction methods, organ preservation fluid and renal parenchymal tissues were tested for SARS-CoV-2 from the kidney of a SARS-CoV-2-positive donor prior to transplantation. The recipient has remained SARS-CoV-2 negative and clinically well, with excellent graft function 120 days post-transplantation. Oxford University Press 2022-07-05 /pmc/articles/PMC9258928/ /pubmed/35813455 http://dx.doi.org/10.1093/jscr/rjac314 Text en Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2022. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Zhang, Jared R Kueht, Michael Lea, A Scott Stevenson, Heather L Gosnell, Joseph Ren, Ping Nielsen, Marisa C Miller, Aaron Mujtaba, Muhammad Fair, Jeffrey Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor |
title | Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor |
title_full | Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor |
title_fullStr | Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor |
title_full_unstemmed | Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor |
title_short | Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor |
title_sort | multisite biologic tissue sars-cov-2 pcr testing in kidney transplantation from a covid-positive donor |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258928/ https://www.ncbi.nlm.nih.gov/pubmed/35813455 http://dx.doi.org/10.1093/jscr/rjac314 |
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