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Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor

With a high community transmission rate, SARS-CoV-2 has profoundly exacerbated the shortage of organs. Although the risk of donor-recipient transmission of SARS-CoV-2 is anecdotally low, an organ-specific infection analysis of procured organs from SARS-CoV-2 positive donors has yet to be established...

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Autores principales: Zhang, Jared R, Kueht, Michael, Lea, A Scott, Stevenson, Heather L, Gosnell, Joseph, Ren, Ping, Nielsen, Marisa C, Miller, Aaron, Mujtaba, Muhammad, Fair, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258928/
https://www.ncbi.nlm.nih.gov/pubmed/35813455
http://dx.doi.org/10.1093/jscr/rjac314
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author Zhang, Jared R
Kueht, Michael
Lea, A Scott
Stevenson, Heather L
Gosnell, Joseph
Ren, Ping
Nielsen, Marisa C
Miller, Aaron
Mujtaba, Muhammad
Fair, Jeffrey
author_facet Zhang, Jared R
Kueht, Michael
Lea, A Scott
Stevenson, Heather L
Gosnell, Joseph
Ren, Ping
Nielsen, Marisa C
Miller, Aaron
Mujtaba, Muhammad
Fair, Jeffrey
author_sort Zhang, Jared R
collection PubMed
description With a high community transmission rate, SARS-CoV-2 has profoundly exacerbated the shortage of organs. Although the risk of donor-recipient transmission of SARS-CoV-2 is anecdotally low, an organ-specific infection analysis of procured organs from SARS-CoV-2 positive donors has yet to be established. Using a combination of clinically available and research-only polymerase chain reaction methods, organ preservation fluid and renal parenchymal tissues were tested for SARS-CoV-2 from the kidney of a SARS-CoV-2-positive donor prior to transplantation. The recipient has remained SARS-CoV-2 negative and clinically well, with excellent graft function 120 days post-transplantation.
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spelling pubmed-92589282022-07-07 Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor Zhang, Jared R Kueht, Michael Lea, A Scott Stevenson, Heather L Gosnell, Joseph Ren, Ping Nielsen, Marisa C Miller, Aaron Mujtaba, Muhammad Fair, Jeffrey J Surg Case Rep Case Report With a high community transmission rate, SARS-CoV-2 has profoundly exacerbated the shortage of organs. Although the risk of donor-recipient transmission of SARS-CoV-2 is anecdotally low, an organ-specific infection analysis of procured organs from SARS-CoV-2 positive donors has yet to be established. Using a combination of clinically available and research-only polymerase chain reaction methods, organ preservation fluid and renal parenchymal tissues were tested for SARS-CoV-2 from the kidney of a SARS-CoV-2-positive donor prior to transplantation. The recipient has remained SARS-CoV-2 negative and clinically well, with excellent graft function 120 days post-transplantation. Oxford University Press 2022-07-05 /pmc/articles/PMC9258928/ /pubmed/35813455 http://dx.doi.org/10.1093/jscr/rjac314 Text en Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2022. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Zhang, Jared R
Kueht, Michael
Lea, A Scott
Stevenson, Heather L
Gosnell, Joseph
Ren, Ping
Nielsen, Marisa C
Miller, Aaron
Mujtaba, Muhammad
Fair, Jeffrey
Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor
title Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor
title_full Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor
title_fullStr Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor
title_full_unstemmed Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor
title_short Multisite biologic tissue SARS-CoV-2 PCR testing in kidney transplantation from a COVID-positive donor
title_sort multisite biologic tissue sars-cov-2 pcr testing in kidney transplantation from a covid-positive donor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258928/
https://www.ncbi.nlm.nih.gov/pubmed/35813455
http://dx.doi.org/10.1093/jscr/rjac314
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