Cargando…

Structural basis for the calmodulin-mediated activation of eukaryotic elongation factor 2 kinase

Translation is a tightly regulated process that ensures optimal protein quality and enables adaptation to energy/nutrient availability. The α-kinase eukaryotic elongation factor 2 kinase (eEF-2K), a key regulator of translation, specifically phosphorylates the guanosine triphosphatase eEF-2, thereby...

Descripción completa

Detalles Bibliográficos
Autores principales:	Piserchio, Andrea, Isiorho, Eta A., Long, Kimberly, Bohanon, Amanda L., Kumar, Eric A., Will, Nathan, Jeruzalmi, David, Dalby, Kevin N., Ghose, Ranajeet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258954/ https://www.ncbi.nlm.nih.gov/pubmed/35857468 http://dx.doi.org/10.1126/sciadv.abo2039

Ejemplares similares

ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin
por: Piserchio, Andrea, et al.
Publicado: (2023)

Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor
por: Piserchio, Andrea, et al.
Publicado: (2023)

An ATPase with a twist: A unique mechanism underlies the activity of the bacterial tyrosine kinase, Wzc
por: Hajredini, Fatlum, et al.
Publicado: (2021)

Structural basis for the recognition of the bacterial tyrosine kinase Wzc by its cognate tyrosine phosphatase Wzb
por: Alphonse, Sébastien, et al.
Publicado: (2022)

Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8(+) T cells
por: Das, Jugal Kishore, et al.
Publicado: (2022)

Structural basis for C-type inactivation in a Shaker family voltage-gated K(+) channel
por: Reddi, Ravikumar, et al.
Publicado: (2022)

The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma
por: Wang, Donghai, et al.
Publicado: (2023)

The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats
por: Huda, Armela, et al.
Publicado: (2023)

Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution
por: Akıl, Caner, et al.
Publicado: (2022)

Programmable RNA-guided DNA endonucleases are widespread in eukaryotes and their viruses
por: Jiang, Kaiyi, et al.
Publicado: (2023)

Auxin promotes hypocotyl elongation by enhancing BZR1 nuclear accumulation in Arabidopsis
por: Yu, Zipeng, et al.
Publicado: (2023)

Aclarubicin stimulates RNA polymerase II elongation at closely spaced divergent promoters
por: Wooten, Matthew, et al.
Publicado: (2023)

A unique flavoenzyme operates in ubiquinone biosynthesis in photosynthesis-related eukaryotes
por: Xu, Jing-Jing, et al.
Publicado: (2021)

Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum
por: Laube, Eike, et al.
Publicado: (2022)

The minimal intrinsic stochasticity of constitutively expressed eukaryotic genes is sub-Poissonian
por: Weidemann, Douglas E., et al.
Publicado: (2023)

An orthologous gene coevolution network provides insight into eukaryotic cellular and genomic structure and function
por: Steenwyk, Jacob L., et al.
Publicado: (2022)

Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation
por: Hochheiser, Inga V., et al.
Publicado: (2022)

COP1 dynamics integrate conflicting seasonal light and thermal cues in the control of Arabidopsis elongation
por: Nieto, Cristina, et al.
Publicado: (2022)

Pointed-end processive elongation of actin filaments by Vibrio effectors VopF and VopL
por: Kudryashova, Elena, et al.
Publicado: (2022)

Structural basis of bacteriophage T5 infection trigger and E. coli cell wall perforation
por: Linares, Romain, et al.
Publicado: (2023)

6mA-Sniper: Quantifying 6mA sites in eukaryotes at single-nucleotide resolution
por: Zhang, Jie, et al.
Publicado: (2023)

RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells
por: Akturk, Anil, et al.
Publicado: (2022)

ELOA3: A primate-specific RNA polymerase II elongation factor encoded by a tandem repeat gene cluster
por: Morgan, Marc A. J., et al.
Publicado: (2023)

Uncovering the genomic basis of an extraordinary plant invasion
por: Bieker, Vanessa C., et al.
Publicado: (2022)

CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation
por: Qiu, Min, et al.
Publicado: (2023)

Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification
por: Bärland, Natalie, et al.
Publicado: (2022)

Structural basis of purine nucleotide inhibition of human uncoupling protein 1
por: Jones, Scott A., et al.
Publicado: (2023)

Directed assembly of genetically engineered eukaryotic cells into living functional materials via ultrahigh-affinity protein interactions
por: Yi, Qikun, et al.
Publicado: (2022)

Developmental basis of evolutionary lung loss in plethodontid salamanders
por: Lewis, Zachary R., et al.
Publicado: (2022)

Structural basis for motilin and erythromycin recognition by motilin receptor
por: You, Chongzhao, et al.
Publicado: (2023)

Structural basis of DegP protease temperature-dependent activation
por: Šulskis, Darius, et al.
Publicado: (2021)

Structural basis for HCMV Pentamer receptor recognition and antibody neutralization
por: Kschonsak, Marc, et al.
Publicado: (2022)

Structural basis for long-chain isoprenoid synthesis by cis-prenyltransferases
por: Giladi, Moshe, et al.
Publicado: (2022)

Structural basis for CEP192-mediated regulation of centrosomal AURKA
por: Park, Jin-Gyeong, et al.
Publicado: (2023)

Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias
por: Yen, Yu-Chen, et al.
Publicado: (2022)

Enhancing HIV-1 latency reversal through regulating the elongating RNA Pol II pause-release by a small-molecule disruptor of PAF1C
por: Soliman, Shimaa H. A., et al.
Publicado: (2023)

Genomic basis for skin phenotype and cold adaptation in the extinct Steller’s sea cow
por: Le Duc, Diana, et al.
Publicado: (2022)

Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies
por: Wrapp, Daniel, et al.
Publicado: (2022)

Structural basis of autoinhibition of the human NHE3-CHP1 complex
por: Dong, Yanli, et al.
Publicado: (2022)

Molecular basis of the key regulator WRINKLED1 in plant oil biosynthesis
por: Qiao, Zhu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4db8obntca3vavude4qg9r746g