Cargando…

Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814

New variants of the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) emerged and spread rapidly all over the world, which strongly supports the need for pharmacological options to complement vaccine strategies. Main protease (M(pro) or 3CL(pro)) is a critical enzyme in the life cycle of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jian, Lin, Cheng, Zhou, Xuelan, Zhong, Fanglin, Zeng, Pei, McCormick, Peter J., Jiang, Haihai, Zhang, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259064/ https://www.ncbi.nlm.nih.gov/pubmed/35809383 http://dx.doi.org/10.1016/j.jmb.2022.167706

Ejemplares similares

Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332
por: Li, Jian, et al.
Publicado: (2022)

Crystal structures of main protease (M(pro)) mutants of SARS-CoV-2 variants bound to PF-07304814
por: Jiang, Haihai, et al.
Publicado: (2023)

Structural basis of main proteases of HCoV-229E bound to inhibitor PF-07304814 and PF-07321332
por: Zhou, Yanru, et al.
Publicado: (2023)

Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor
por: Hu, Xiaohui, et al.
Publicado: (2022)

Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus
por: Zhang, Yuting, et al.
Publicado: (2022)

Crystal structures of main proteases of SARS-CoV-2 variants bound to a benzothiazole-based inhibitor: Crystal structures of M (pro) mutants bound to YH-53
por: Luo, Jiqing, et al.
Publicado: (2023)

Review of preclinical data of PF-07304814 and its active metabolite derivatives against SARS-CoV-2 infection
por: Chen, Wujun, et al.
Publicado: (2022)

Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Intravenous Infusions of PF-07304814 (Lufotrelvir) in Participants Hospitalized With COVID-19
por: Robinson, Philip, et al.
Publicado: (2023)

Structure of SARS-CoV-2 main protease in the apo state
por: Zhou, Xuelan, et al.
Publicado: (2020)

Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode
por: Li, Jian, et al.
Publicado: (2021)

Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses
por: Zvornicanin, Sarah N., et al.
Publicado: (2023)

Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332
por: Zhao, Yao, et al.
Publicado: (2021)

Quaternary Structure of the SARS Coronavirus Main Protease
por: Chang, Gu-Gang
Publicado: (2009)

Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
por: Yang, Haitao, et al.
Publicado: (2005)

Characterization of the non-covalent interaction between the PF-07321332 inhibitor and the SARS-CoV-2 main protease
por: Macchiagodena, Marina, et al.
Publicado: (2022)

Individual and common inhibitors of coronavirus and picornavirus main proteases
por: Kuo, Chih-Jung, et al.
Publicado: (2009)

Correction: Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
por: Yang, Haitao, et al.
Publicado: (2005)

Novel Small-Molecule Scaffolds as Candidates against the SARS Coronavirus 2 Main Protease: A Fragment-Guided in Silico Approach
por: Augustin, Teresa L., et al.
Publicado: (2020)

Ligand-based discovery of coronavirus main protease inhibitors using MACAW molecular embeddings
por: Dong, Jie, et al.
Publicado: (2022)

Structural Basis of Potential Inhibitors Targeting SARS-CoV-2 Main Protease
por: Mengist, Hylemariam Mihiretie, et al.
Publicado: (2021)

Supervised Molecular Dynamics (SuMD) Insights into the mechanism of action of SARS-CoV-2 main protease inhibitor PF-07321332
por: Pavan, Matteo, et al.
Publicado: (2021)

Xanthohumol Is a Potent Pan-Inhibitor of Coronaviruses Targeting Main Protease
por: Lin, Yuxi, et al.
Publicado: (2021)

A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir
por: Vankadara, Subramanyam, et al.
Publicado: (2022)

Structural analysis of the coronavirus main protease for the design of pan-variant inhibitors
por: Rungruangmaitree, Runchana, et al.
Publicado: (2023)

Crystal Structure of Human Coronavirus NL63 Main Protease in Complex With an Inhibitor
por: Yang, Kailin, et al.
Publicado: (2015)

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease
por: Zhu, Lili, et al.
Publicado: (2011)

Effect of pH on stability of dimer structure of the main protease of coronavirus-2
por: Boonamnaj, Panisak, et al.
Publicado: (2022)

In silico fight against novel coronavirus by finding chromone derivatives as inhibitor of coronavirus main proteases enzyme
por: Sepay, Nayim, et al.
Publicado: (2020)

Bounding basis reduction properties
por: Neumaier, Arnold
Publicado: (2016)

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
por: Dai, Wenhao, et al.
Publicado: (2020)

The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to reduce COVID-19-related hospitalizations
por: Joyce, Ryan P., et al.
Publicado: (2022)

Computational screening for potential drug candidates against the SARS-CoV-2 main protease
por: Silva Andrade, Bruno, et al.
Publicado: (2020)

Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir
por: Bai, Yu, et al.
Publicado: (2021)

Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT
por: Shafik, Sarah Heckmatt, et al.
Publicado: (2022)

Reversible Unfolding of the Severe Acute Respiratory Syndrome Coronavirus Main Protease in Guanidinium Chloride
por: Chang, Hui-Ping, et al.
Publicado: (2007)

Mutation of Glu-166 Blocks the Substrate-Induced Dimerization of SARS Coronavirus Main Protease
por: Cheng, Shu-Chun, et al.
Publicado: (2010)

Critical Assessment of the Important Residues Involved in the Dimerization and Catalysis of MERS Coronavirus Main Protease
por: Ho, Bo-Lin, et al.
Publicado: (2015)

QM/QM studies for Michael reaction in coronavirus main protease (3CL(Pro))
por: Taranto, Alex G., et al.
Publicado: (2008)

The Molecular Mechanism of Domain Swapping of the C-Terminal Domain of the SARS-Coronavirus Main Protease
por: Terse, Vishram L., et al.
Publicado: (2021)

The Main Protease of SARS-CoV-2 as a Target for Phytochemicals against Coronavirus
por: Issa, Shaza S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_v5dl9q474prfk1kpi1o4271fd5