PARP Inhibitor Insensitivity to BRCA1/2 Monoallelic Mutations in Microsatellite Instability-High Cancers

PURPOSE: To examine the overlap of homologous recombination deficiency (HRD) and microsatellite instability high (MSI-H) status, and to dissect driver versus bystander status of BRCA1/2 mutations (BRCAm) in this context. METHODS: A pan-cancer comprehensive genomic profiling cohort (n = 213,199) was...

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Detalles Bibliográficos
Autores principales: Sokol, Ethan S., Jin, Dexter X., Fine, Alexander, Trabucco, Sally E., Maund, Sophia, Frampton, Garrett, Molinero, Luciana, Antonarakis, Emmanuel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2022
Materias:
ORIGINAL REPORTS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259120/
https://www.ncbi.nlm.nih.gov/pubmed/35772050
http://dx.doi.org/10.1200/PO.21.00531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259120/
https://www.ncbi.nlm.nih.gov/pubmed/35772050
http://dx.doi.org/10.1200/PO.21.00531

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