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Cerebral hemodynamics in children with sickle cell disease in India: An observational cohort study

India has the second highest number of cases of sickle cell disease (SCD) and affects the most socioeconomically disadvantaged communities living in a horizontal belt from Gujarat to Odisha state. Despite high prevalence, information about cerebral hemodynamics among children with SCD in India remai...

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Autores principales: Gajjar, Bhakti, Sharma, Sanjay, Khan, Erum, Sharma, Pranita, Jain, Pawan, Goel, Vikas, Neral, Arvind, Patel, Jyotish, Parmar, Mamta, Sharma, Kanika, Sharma, Vijay K., Sharma, Arvind K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259145/
https://www.ncbi.nlm.nih.gov/pubmed/35801747
http://dx.doi.org/10.1097/MD.0000000000029882
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author Gajjar, Bhakti
Sharma, Sanjay
Khan, Erum
Sharma, Pranita
Jain, Pawan
Goel, Vikas
Neral, Arvind
Patel, Jyotish
Parmar, Mamta
Sharma, Kanika
Sharma, Vijay K.
Sharma, Arvind K.
author_facet Gajjar, Bhakti
Sharma, Sanjay
Khan, Erum
Sharma, Pranita
Jain, Pawan
Goel, Vikas
Neral, Arvind
Patel, Jyotish
Parmar, Mamta
Sharma, Kanika
Sharma, Vijay K.
Sharma, Arvind K.
author_sort Gajjar, Bhakti
collection PubMed
description India has the second highest number of cases of sickle cell disease (SCD) and affects the most socioeconomically disadvantaged communities living in a horizontal belt from Gujarat to Odisha state. Despite high prevalence, information about cerebral hemodynamics among children with SCD in India remains scarcely described. We performed transcranial Doppler (TCD) to assess cerebral hemodynamics among Indian children with SCD and evaluated their association with clinical and hematological parameters. Children aged 3-18years, diagnosed with SCD living in Raipur in Chhattisgarh and Ahmedabad in Gujarat state were recruited. TCD was performed to obtain flow velocities from middle cerebral (MCA), intracranial internal carotid (ICA) and basilar artery. Associations were evaluated between timed-average-mean-maximum velocities (TAMMV) and various clinical and hematological parameters. Our prospective study included 62 consecutive children with known SCD. Mean ± SD age of the study population was 9.8 ± 3.9 years and 31 (50%) were male. Mean ± SD hemoglobin was 8.64 ± 1.34 Gm/dL while the mean HbSS ± SD was 70.25 ± 15.27%. While 6 (9.6%) children had suffered from stroke during previous 2 years, 7 (11%) demonstrated abnormal TAMMV. Higher HbSS level along with history of iron chelation therapy, blood transfusion and/or stroke showed a trend towards having higher TAMMV. Stroke and cerebral hemodynamic alterations are common among Indian children with SCD. Larger studies with detailed neuroimaging and genetic evaluations are needed for better understanding, characterization, risk stratification as well as optimization of the timing of blood transfusion to reduce physical disabilities among Indian children with SCD.
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spelling pubmed-92591452022-07-08 Cerebral hemodynamics in children with sickle cell disease in India: An observational cohort study Gajjar, Bhakti Sharma, Sanjay Khan, Erum Sharma, Pranita Jain, Pawan Goel, Vikas Neral, Arvind Patel, Jyotish Parmar, Mamta Sharma, Kanika Sharma, Vijay K. Sharma, Arvind K. Medicine (Baltimore) Research Article India has the second highest number of cases of sickle cell disease (SCD) and affects the most socioeconomically disadvantaged communities living in a horizontal belt from Gujarat to Odisha state. Despite high prevalence, information about cerebral hemodynamics among children with SCD in India remains scarcely described. We performed transcranial Doppler (TCD) to assess cerebral hemodynamics among Indian children with SCD and evaluated their association with clinical and hematological parameters. Children aged 3-18years, diagnosed with SCD living in Raipur in Chhattisgarh and Ahmedabad in Gujarat state were recruited. TCD was performed to obtain flow velocities from middle cerebral (MCA), intracranial internal carotid (ICA) and basilar artery. Associations were evaluated between timed-average-mean-maximum velocities (TAMMV) and various clinical and hematological parameters. Our prospective study included 62 consecutive children with known SCD. Mean ± SD age of the study population was 9.8 ± 3.9 years and 31 (50%) were male. Mean ± SD hemoglobin was 8.64 ± 1.34 Gm/dL while the mean HbSS ± SD was 70.25 ± 15.27%. While 6 (9.6%) children had suffered from stroke during previous 2 years, 7 (11%) demonstrated abnormal TAMMV. Higher HbSS level along with history of iron chelation therapy, blood transfusion and/or stroke showed a trend towards having higher TAMMV. Stroke and cerebral hemodynamic alterations are common among Indian children with SCD. Larger studies with detailed neuroimaging and genetic evaluations are needed for better understanding, characterization, risk stratification as well as optimization of the timing of blood transfusion to reduce physical disabilities among Indian children with SCD. Lippincott Williams & Wilkins 2022-07-08 /pmc/articles/PMC9259145/ /pubmed/35801747 http://dx.doi.org/10.1097/MD.0000000000029882 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gajjar, Bhakti
Sharma, Sanjay
Khan, Erum
Sharma, Pranita
Jain, Pawan
Goel, Vikas
Neral, Arvind
Patel, Jyotish
Parmar, Mamta
Sharma, Kanika
Sharma, Vijay K.
Sharma, Arvind K.
Cerebral hemodynamics in children with sickle cell disease in India: An observational cohort study
title Cerebral hemodynamics in children with sickle cell disease in India: An observational cohort study
title_full Cerebral hemodynamics in children with sickle cell disease in India: An observational cohort study
title_fullStr Cerebral hemodynamics in children with sickle cell disease in India: An observational cohort study
title_full_unstemmed Cerebral hemodynamics in children with sickle cell disease in India: An observational cohort study
title_short Cerebral hemodynamics in children with sickle cell disease in India: An observational cohort study
title_sort cerebral hemodynamics in children with sickle cell disease in india: an observational cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259145/
https://www.ncbi.nlm.nih.gov/pubmed/35801747
http://dx.doi.org/10.1097/MD.0000000000029882
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