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Increased severity of complications after therapeutic ERCP in geriatric patients with chronic pancreatitis: An observational study
Studies of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in geriatric patients have mainly examined patients with biliary diseases, rather than chronic pancreatitis (CP). This study aimed to evaluate the safety and success rate of therapeutic ERCP in geriatric patients with CP. T...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259179/ https://www.ncbi.nlm.nih.gov/pubmed/35801792 http://dx.doi.org/10.1097/MD.0000000000029753 |
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author | Guo, Ji-Yao Zhu, Jia-Hui Pan, Jun Wang, Yuan-Chen Qian, Yang-Yang Hu, Liang-Hao He, Chao-Hui Zou, Wen-Bin |
author_facet | Guo, Ji-Yao Zhu, Jia-Hui Pan, Jun Wang, Yuan-Chen Qian, Yang-Yang Hu, Liang-Hao He, Chao-Hui Zou, Wen-Bin |
author_sort | Guo, Ji-Yao |
collection | PubMed |
description | Studies of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in geriatric patients have mainly examined patients with biliary diseases, rather than chronic pancreatitis (CP). This study aimed to evaluate the safety and success rate of therapeutic ERCP in geriatric patients with CP. The medical records of patients with CP aged over 65 years (group A) were retrospectively collected in a tertiary hospital from January 2013 to December 2018. Sex-matched CP patients under 65 years (group B) were randomly selected into the control group (matching ratio = 1:2). The success rate and the complication rate of therapeutic ERCP in 2 groups were compared. The risk factors for post-ERCP pancreatitis were investigated by univariate and multivariate analyses. A total of 268 ERCPs were performed in 179 patients of group A and 612 ERCPs in 358 patients of group B. The success rate of ERCP in group A was similar to that of group B (92.16% vs 92.32%; P = .936). The overall incidence of post-ERCP complications was 7.09% (19/268) and 5.72% (35/612) in group A and B, respectively (P = .436). However, geriatric patients had a significantly increased occurrence of moderate to severe complications (2.61% vs 0.16%; P = .002). Female gender (odds ratio [OR] = 3.40; P = .046), pancreas divisum (OR = 7.15; P = .049), dorsal pancreatogram (OR = 7.40; P = .010), and lithotripsy (OR = 0.15; P = .016) were significantly associated with risk of post-ERCP pancreatitis in geriatric patients. Therapeutic ERCP is safe and feasible in elderly patients with CP. However, occurrence of moderate to severe complications after ERCP increased in geriatric patients. |
format | Online Article Text |
id | pubmed-9259179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-92591792022-07-08 Increased severity of complications after therapeutic ERCP in geriatric patients with chronic pancreatitis: An observational study Guo, Ji-Yao Zhu, Jia-Hui Pan, Jun Wang, Yuan-Chen Qian, Yang-Yang Hu, Liang-Hao He, Chao-Hui Zou, Wen-Bin Medicine (Baltimore) Research Article Studies of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in geriatric patients have mainly examined patients with biliary diseases, rather than chronic pancreatitis (CP). This study aimed to evaluate the safety and success rate of therapeutic ERCP in geriatric patients with CP. The medical records of patients with CP aged over 65 years (group A) were retrospectively collected in a tertiary hospital from January 2013 to December 2018. Sex-matched CP patients under 65 years (group B) were randomly selected into the control group (matching ratio = 1:2). The success rate and the complication rate of therapeutic ERCP in 2 groups were compared. The risk factors for post-ERCP pancreatitis were investigated by univariate and multivariate analyses. A total of 268 ERCPs were performed in 179 patients of group A and 612 ERCPs in 358 patients of group B. The success rate of ERCP in group A was similar to that of group B (92.16% vs 92.32%; P = .936). The overall incidence of post-ERCP complications was 7.09% (19/268) and 5.72% (35/612) in group A and B, respectively (P = .436). However, geriatric patients had a significantly increased occurrence of moderate to severe complications (2.61% vs 0.16%; P = .002). Female gender (odds ratio [OR] = 3.40; P = .046), pancreas divisum (OR = 7.15; P = .049), dorsal pancreatogram (OR = 7.40; P = .010), and lithotripsy (OR = 0.15; P = .016) were significantly associated with risk of post-ERCP pancreatitis in geriatric patients. Therapeutic ERCP is safe and feasible in elderly patients with CP. However, occurrence of moderate to severe complications after ERCP increased in geriatric patients. Lippincott Williams & Wilkins 2022-07-08 /pmc/articles/PMC9259179/ /pubmed/35801792 http://dx.doi.org/10.1097/MD.0000000000029753 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | Research Article Guo, Ji-Yao Zhu, Jia-Hui Pan, Jun Wang, Yuan-Chen Qian, Yang-Yang Hu, Liang-Hao He, Chao-Hui Zou, Wen-Bin Increased severity of complications after therapeutic ERCP in geriatric patients with chronic pancreatitis: An observational study |
title | Increased severity of complications after therapeutic ERCP in geriatric patients with chronic pancreatitis: An observational study |
title_full | Increased severity of complications after therapeutic ERCP in geriatric patients with chronic pancreatitis: An observational study |
title_fullStr | Increased severity of complications after therapeutic ERCP in geriatric patients with chronic pancreatitis: An observational study |
title_full_unstemmed | Increased severity of complications after therapeutic ERCP in geriatric patients with chronic pancreatitis: An observational study |
title_short | Increased severity of complications after therapeutic ERCP in geriatric patients with chronic pancreatitis: An observational study |
title_sort | increased severity of complications after therapeutic ercp in geriatric patients with chronic pancreatitis: an observational study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259179/ https://www.ncbi.nlm.nih.gov/pubmed/35801792 http://dx.doi.org/10.1097/MD.0000000000029753 |
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