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Trisomy 8-positive Polycythemia Vera Complicated with Intestinal Behçet's-like Disease: A New Perspective for a Clinical Approach

Behçet's disease (BD) is a multisystem inflammatory disease of unknown origin. It rarely but occasionally occurs together with myelodysplastic syndrome and primary myelofibrosis. Trisomy 8 is one of the most common cytogenetic abnormalities in myeloid neoplasms; however, the association of BD w...

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Autores principales: Mori, Yuki, Iwamoto, Fumihiko, Kuno, Toru, Kobayashi, Shoji, Yoshida, Takashi, Yamaguchi, Tatsuya, Takano, Shinichi, Kondo, Tetsuo, Kirito, Keita, Enomoto, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259299/
https://www.ncbi.nlm.nih.gov/pubmed/34744109
http://dx.doi.org/10.2169/internalmedicine.8395-21
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author Mori, Yuki
Iwamoto, Fumihiko
Kuno, Toru
Kobayashi, Shoji
Yoshida, Takashi
Yamaguchi, Tatsuya
Takano, Shinichi
Kondo, Tetsuo
Kirito, Keita
Enomoto, Nobuyuki
author_facet Mori, Yuki
Iwamoto, Fumihiko
Kuno, Toru
Kobayashi, Shoji
Yoshida, Takashi
Yamaguchi, Tatsuya
Takano, Shinichi
Kondo, Tetsuo
Kirito, Keita
Enomoto, Nobuyuki
author_sort Mori, Yuki
collection PubMed
description Behçet's disease (BD) is a multisystem inflammatory disease of unknown origin. It rarely but occasionally occurs together with myelodysplastic syndrome and primary myelofibrosis. Trisomy 8 is one of the most common cytogenetic abnormalities in myeloid neoplasms; however, the association of BD with polycythemia vera (PV) and trisomy 8 has not been reported. A 70-year-old woman, diagnosed with PV and treated with hydroxyurea, had bloody stool due to multiple ulcers in the ileocecal region. Considering the lack of a response to treatment and other features, we suspected complication with intestinal Behçet's-like disease. Our case suggests relationships among BD, trisomy 8, and PV.
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spelling pubmed-92592992022-07-19 Trisomy 8-positive Polycythemia Vera Complicated with Intestinal Behçet's-like Disease: A New Perspective for a Clinical Approach Mori, Yuki Iwamoto, Fumihiko Kuno, Toru Kobayashi, Shoji Yoshida, Takashi Yamaguchi, Tatsuya Takano, Shinichi Kondo, Tetsuo Kirito, Keita Enomoto, Nobuyuki Intern Med Case Report Behçet's disease (BD) is a multisystem inflammatory disease of unknown origin. It rarely but occasionally occurs together with myelodysplastic syndrome and primary myelofibrosis. Trisomy 8 is one of the most common cytogenetic abnormalities in myeloid neoplasms; however, the association of BD with polycythemia vera (PV) and trisomy 8 has not been reported. A 70-year-old woman, diagnosed with PV and treated with hydroxyurea, had bloody stool due to multiple ulcers in the ileocecal region. Considering the lack of a response to treatment and other features, we suspected complication with intestinal Behçet's-like disease. Our case suggests relationships among BD, trisomy 8, and PV. The Japanese Society of Internal Medicine 2021-11-06 2022-06-01 /pmc/articles/PMC9259299/ /pubmed/34744109 http://dx.doi.org/10.2169/internalmedicine.8395-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Mori, Yuki
Iwamoto, Fumihiko
Kuno, Toru
Kobayashi, Shoji
Yoshida, Takashi
Yamaguchi, Tatsuya
Takano, Shinichi
Kondo, Tetsuo
Kirito, Keita
Enomoto, Nobuyuki
Trisomy 8-positive Polycythemia Vera Complicated with Intestinal Behçet's-like Disease: A New Perspective for a Clinical Approach
title Trisomy 8-positive Polycythemia Vera Complicated with Intestinal Behçet's-like Disease: A New Perspective for a Clinical Approach
title_full Trisomy 8-positive Polycythemia Vera Complicated with Intestinal Behçet's-like Disease: A New Perspective for a Clinical Approach
title_fullStr Trisomy 8-positive Polycythemia Vera Complicated with Intestinal Behçet's-like Disease: A New Perspective for a Clinical Approach
title_full_unstemmed Trisomy 8-positive Polycythemia Vera Complicated with Intestinal Behçet's-like Disease: A New Perspective for a Clinical Approach
title_short Trisomy 8-positive Polycythemia Vera Complicated with Intestinal Behçet's-like Disease: A New Perspective for a Clinical Approach
title_sort trisomy 8-positive polycythemia vera complicated with intestinal behçet's-like disease: a new perspective for a clinical approach
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259299/
https://www.ncbi.nlm.nih.gov/pubmed/34744109
http://dx.doi.org/10.2169/internalmedicine.8395-21
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