The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient

We herein report the case of a 78-year-old woman who was diagnosed as having disseminated herpes zoster (DHZ) complicated with probable varicella-zoster pneumonia during maintenance therapy for microscopic polyangiitis. Because the patient had severe renal dysfunction, amenamevir administration was...

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Autores principales: Kobayashi, Hiroki, Yoshida, Yusuke, Komoshita, Tomoki, Suma, Harumichi, Hosokawa, Yohei, Hirose, Yoshikazu, Sugimoto, Tomohiro, Mokuda, Sho, Hirata, Shintaro, Sugiyama, Eiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259304/
https://www.ncbi.nlm.nih.gov/pubmed/34776482
http://dx.doi.org/10.2169/internalmedicine.8104-21
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author Kobayashi, Hiroki
Yoshida, Yusuke
Komoshita, Tomoki
Suma, Harumichi
Hosokawa, Yohei
Hirose, Yoshikazu
Sugimoto, Tomohiro
Mokuda, Sho
Hirata, Shintaro
Sugiyama, Eiji
author_facet Kobayashi, Hiroki
Yoshida, Yusuke
Komoshita, Tomoki
Suma, Harumichi
Hosokawa, Yohei
Hirose, Yoshikazu
Sugimoto, Tomohiro
Mokuda, Sho
Hirata, Shintaro
Sugiyama, Eiji
author_sort Kobayashi, Hiroki
collection PubMed
description We herein report the case of a 78-year-old woman who was diagnosed as having disseminated herpes zoster (DHZ) complicated with probable varicella-zoster pneumonia during maintenance therapy for microscopic polyangiitis. Because the patient had severe renal dysfunction, amenamevir administration was started to avoid any neurotoxicity of acyclovir, which is suggested to be optimal for treatment. It ameliorated her symptoms without any adverse events. This is the first report suggesting the efficacy of amenamevir in the treatment of severe herpes zoster infection with coexisting DHZ and probable varicella-zoster pneumonia. Amenamevir could thus be a treatment option for severe varicella zoster virus infections.
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spelling pubmed-92593042022-07-19 The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient Kobayashi, Hiroki Yoshida, Yusuke Komoshita, Tomoki Suma, Harumichi Hosokawa, Yohei Hirose, Yoshikazu Sugimoto, Tomohiro Mokuda, Sho Hirata, Shintaro Sugiyama, Eiji Intern Med Case Report We herein report the case of a 78-year-old woman who was diagnosed as having disseminated herpes zoster (DHZ) complicated with probable varicella-zoster pneumonia during maintenance therapy for microscopic polyangiitis. Because the patient had severe renal dysfunction, amenamevir administration was started to avoid any neurotoxicity of acyclovir, which is suggested to be optimal for treatment. It ameliorated her symptoms without any adverse events. This is the first report suggesting the efficacy of amenamevir in the treatment of severe herpes zoster infection with coexisting DHZ and probable varicella-zoster pneumonia. Amenamevir could thus be a treatment option for severe varicella zoster virus infections. The Japanese Society of Internal Medicine 2021-11-13 2022-06-01 /pmc/articles/PMC9259304/ /pubmed/34776482 http://dx.doi.org/10.2169/internalmedicine.8104-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kobayashi, Hiroki
Yoshida, Yusuke
Komoshita, Tomoki
Suma, Harumichi
Hosokawa, Yohei
Hirose, Yoshikazu
Sugimoto, Tomohiro
Mokuda, Sho
Hirata, Shintaro
Sugiyama, Eiji
The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient
title The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient
title_full The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient
title_fullStr The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient
title_full_unstemmed The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient
title_short The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient
title_sort efficacy of amenamevir for the treatment of disseminated herpes zoster complicated with probable varicella-zoster pneumonia in an immunocompromised patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259304/
https://www.ncbi.nlm.nih.gov/pubmed/34776482
http://dx.doi.org/10.2169/internalmedicine.8104-21
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