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Severe Anemia Due to Cold Agglutinin Syndrome in a COVID-19 Patient with IgM Monoclonal Gammopathy of Undetermined Significance Successfully Treated with Corticosteroids
Secondary cold agglutinin syndrome (CAS) is autoimmune hemolytic anemia secondary to infections and lymphoid disorder. We here report the first Asian case of CAS secondary to novel coronavirus disease 2019 (COVID-19). A 72-year-old Japanese woman presented with a 2-week history of dyspnea and cough,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259319/ https://www.ncbi.nlm.nih.gov/pubmed/35342131 http://dx.doi.org/10.2169/internalmedicine.8647-21 |
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author | Tsukamoto, Yutaka Umeda, Masataka Muto, Yuko Sugimoto, Takashi Yamauchi, Momoko Ando, Koji Ariyoshi, Koya |
author_facet | Tsukamoto, Yutaka Umeda, Masataka Muto, Yuko Sugimoto, Takashi Yamauchi, Momoko Ando, Koji Ariyoshi, Koya |
author_sort | Tsukamoto, Yutaka |
collection | PubMed |
description | Secondary cold agglutinin syndrome (CAS) is autoimmune hemolytic anemia secondary to infections and lymphoid disorder. We here report the first Asian case of CAS secondary to novel coronavirus disease 2019 (COVID-19). A 72-year-old Japanese woman presented with a 2-week history of dyspnea and cough, and laboratory data revealed severe hemolytic anemia with a hemoglobin level of 4.7 g/dL. She was diagnosed with COVID-19, CAS, and monoclonal gammopathy of undetermined significance (MGUS). The anemia responded to corticosteroids administered for COVID-19 and required maintenance therapy. Although corticosteroids are not a standard therapy for CAS, they might be effective for CAS secondary to COVID-19 complicated with MGUS. |
format | Online Article Text |
id | pubmed-9259319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-92593192022-07-19 Severe Anemia Due to Cold Agglutinin Syndrome in a COVID-19 Patient with IgM Monoclonal Gammopathy of Undetermined Significance Successfully Treated with Corticosteroids Tsukamoto, Yutaka Umeda, Masataka Muto, Yuko Sugimoto, Takashi Yamauchi, Momoko Ando, Koji Ariyoshi, Koya Intern Med Case Report Secondary cold agglutinin syndrome (CAS) is autoimmune hemolytic anemia secondary to infections and lymphoid disorder. We here report the first Asian case of CAS secondary to novel coronavirus disease 2019 (COVID-19). A 72-year-old Japanese woman presented with a 2-week history of dyspnea and cough, and laboratory data revealed severe hemolytic anemia with a hemoglobin level of 4.7 g/dL. She was diagnosed with COVID-19, CAS, and monoclonal gammopathy of undetermined significance (MGUS). The anemia responded to corticosteroids administered for COVID-19 and required maintenance therapy. Although corticosteroids are not a standard therapy for CAS, they might be effective for CAS secondary to COVID-19 complicated with MGUS. The Japanese Society of Internal Medicine 2022-03-26 2022-06-01 /pmc/articles/PMC9259319/ /pubmed/35342131 http://dx.doi.org/10.2169/internalmedicine.8647-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Tsukamoto, Yutaka Umeda, Masataka Muto, Yuko Sugimoto, Takashi Yamauchi, Momoko Ando, Koji Ariyoshi, Koya Severe Anemia Due to Cold Agglutinin Syndrome in a COVID-19 Patient with IgM Monoclonal Gammopathy of Undetermined Significance Successfully Treated with Corticosteroids |
title | Severe Anemia Due to Cold Agglutinin Syndrome in a COVID-19 Patient with IgM Monoclonal Gammopathy of Undetermined Significance Successfully Treated with Corticosteroids |
title_full | Severe Anemia Due to Cold Agglutinin Syndrome in a COVID-19 Patient with IgM Monoclonal Gammopathy of Undetermined Significance Successfully Treated with Corticosteroids |
title_fullStr | Severe Anemia Due to Cold Agglutinin Syndrome in a COVID-19 Patient with IgM Monoclonal Gammopathy of Undetermined Significance Successfully Treated with Corticosteroids |
title_full_unstemmed | Severe Anemia Due to Cold Agglutinin Syndrome in a COVID-19 Patient with IgM Monoclonal Gammopathy of Undetermined Significance Successfully Treated with Corticosteroids |
title_short | Severe Anemia Due to Cold Agglutinin Syndrome in a COVID-19 Patient with IgM Monoclonal Gammopathy of Undetermined Significance Successfully Treated with Corticosteroids |
title_sort | severe anemia due to cold agglutinin syndrome in a covid-19 patient with igm monoclonal gammopathy of undetermined significance successfully treated with corticosteroids |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259319/ https://www.ncbi.nlm.nih.gov/pubmed/35342131 http://dx.doi.org/10.2169/internalmedicine.8647-21 |
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