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Polymyalgia Rheumatica Following COVID-19 Vaccination

We herein report a 71-year-old woman presented with a fever, arthralgia, general malaise and leg muscle stiffness following administration of the COVID-19 mRNA vaccine (Comirnaty, Pfizer-BioNTech). Laboratory findings showed an elevated C-reactive protein level and erythrocyte sedimentation rate. In...

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Autores principales: Yokote, Akira, Fujioka, Shinsuke, Takahashi, Nobutaka, Mishima, Takayasu, Tsuboi, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259323/
https://www.ncbi.nlm.nih.gov/pubmed/35342133
http://dx.doi.org/10.2169/internalmedicine.8934-21
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author Yokote, Akira
Fujioka, Shinsuke
Takahashi, Nobutaka
Mishima, Takayasu
Tsuboi, Yoshio
author_facet Yokote, Akira
Fujioka, Shinsuke
Takahashi, Nobutaka
Mishima, Takayasu
Tsuboi, Yoshio
author_sort Yokote, Akira
collection PubMed
description We herein report a 71-year-old woman presented with a fever, arthralgia, general malaise and leg muscle stiffness following administration of the COVID-19 mRNA vaccine (Comirnaty, Pfizer-BioNTech). Laboratory findings showed an elevated C-reactive protein level and erythrocyte sedimentation rate. In addition, Gallium-67 scintigraphy demonstrated an increased uptake in multiple joints. Typing of human leukocyte antigen (HLA) revealed the presence of the DRB1*0404/*0803 allele. These findings met the diagnostic criteria for polymyalgia rheumatica (PMR), and when we started steroid treatment, her symptoms improved rapidly. This patient developed PMR after receiving a COVID-19 mRNA vaccine (Comirnaty, Pfizer-BioNTech). This case is considered to be valuable, as the HLA-DRB1 allele was also confirmed.
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spelling pubmed-92593232022-07-19 Polymyalgia Rheumatica Following COVID-19 Vaccination Yokote, Akira Fujioka, Shinsuke Takahashi, Nobutaka Mishima, Takayasu Tsuboi, Yoshio Intern Med Case Report We herein report a 71-year-old woman presented with a fever, arthralgia, general malaise and leg muscle stiffness following administration of the COVID-19 mRNA vaccine (Comirnaty, Pfizer-BioNTech). Laboratory findings showed an elevated C-reactive protein level and erythrocyte sedimentation rate. In addition, Gallium-67 scintigraphy demonstrated an increased uptake in multiple joints. Typing of human leukocyte antigen (HLA) revealed the presence of the DRB1*0404/*0803 allele. These findings met the diagnostic criteria for polymyalgia rheumatica (PMR), and when we started steroid treatment, her symptoms improved rapidly. This patient developed PMR after receiving a COVID-19 mRNA vaccine (Comirnaty, Pfizer-BioNTech). This case is considered to be valuable, as the HLA-DRB1 allele was also confirmed. The Japanese Society of Internal Medicine 2022-03-26 2022-06-01 /pmc/articles/PMC9259323/ /pubmed/35342133 http://dx.doi.org/10.2169/internalmedicine.8934-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yokote, Akira
Fujioka, Shinsuke
Takahashi, Nobutaka
Mishima, Takayasu
Tsuboi, Yoshio
Polymyalgia Rheumatica Following COVID-19 Vaccination
title Polymyalgia Rheumatica Following COVID-19 Vaccination
title_full Polymyalgia Rheumatica Following COVID-19 Vaccination
title_fullStr Polymyalgia Rheumatica Following COVID-19 Vaccination
title_full_unstemmed Polymyalgia Rheumatica Following COVID-19 Vaccination
title_short Polymyalgia Rheumatica Following COVID-19 Vaccination
title_sort polymyalgia rheumatica following covid-19 vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259323/
https://www.ncbi.nlm.nih.gov/pubmed/35342133
http://dx.doi.org/10.2169/internalmedicine.8934-21
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