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Method development and validation for analysis of phenylalanine, 4‐hydroxyphenyllactic acid and 4‐hydroxyphenylpyruvic acid in serum and urine

Alkaptonuria (AKU) is a rare debilitating autosomal recessive disorder of tyrosine (TYR) metabolism which results in a deficiency of the enzyme homogentisate 1,2‐dioxygenase activity. Several studies have reported the metabolic changes in homogentisic acid (HGA) concentrations and subsequent deposit...

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Detalles Bibliográficos
Autores principales:	Hughes, Andrew T., Milan, Anna M., Shweihdi, Ella, Gallagher, James, Ranganath, Lakshminarayan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Research Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259389/ https://www.ncbi.nlm.nih.gov/pubmed/35822095 http://dx.doi.org/10.1002/jmd2.12287

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