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Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age
While survival has improved for Burkitt lymphoma patients, potential differences in outcome between pediatric and adult patients remain unclear. In both age groups, survival remains poor at relapse. Therefore, we conducted a comparative study in a large pediatric cohort, including 191 cases and 97 s...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259584/ https://www.ncbi.nlm.nih.gov/pubmed/35794096 http://dx.doi.org/10.1038/s41467-022-31355-8 |
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| author | Burkhardt, Birgit Michgehl, Ulf Rohde, Jonas Erdmann, Tabea Berning, Philipp Reutter, Katrin Rohde, Marius Borkhardt, Arndt Burmeister, Thomas Dave, Sandeep Tzankov, Alexandar Dugas, Martin Sandmann, Sarah Fend, Falko Finger, Jasmin Mueller, Stephanie Gökbuget, Nicola Haferlach, Torsten Kern, Wolfgang Hartmann, Wolfgang Klapper, Wolfram Oschlies, Ilske Richter, Julia Kontny, Udo Lutz, Mathias Maecker-Kolhoff, Britta Ott, German Rosenwald, Andreas Siebert, Reiner von Stackelberg, Arend Strahm, Brigitte Woessmann, Wilhelm Zimmermann, Martin Zapukhlyak, Myroslav Grau, Michael Lenz, Georg |
| author_facet | Burkhardt, Birgit Michgehl, Ulf Rohde, Jonas Erdmann, Tabea Berning, Philipp Reutter, Katrin Rohde, Marius Borkhardt, Arndt Burmeister, Thomas Dave, Sandeep Tzankov, Alexandar Dugas, Martin Sandmann, Sarah Fend, Falko Finger, Jasmin Mueller, Stephanie Gökbuget, Nicola Haferlach, Torsten Kern, Wolfgang Hartmann, Wolfgang Klapper, Wolfram Oschlies, Ilske Richter, Julia Kontny, Udo Lutz, Mathias Maecker-Kolhoff, Britta Ott, German Rosenwald, Andreas Siebert, Reiner von Stackelberg, Arend Strahm, Brigitte Woessmann, Wilhelm Zimmermann, Martin Zapukhlyak, Myroslav Grau, Michael Lenz, Georg |
| author_sort | Burkhardt, Birgit |
| collection | PubMed |
| description | While survival has improved for Burkitt lymphoma patients, potential differences in outcome between pediatric and adult patients remain unclear. In both age groups, survival remains poor at relapse. Therefore, we conducted a comparative study in a large pediatric cohort, including 191 cases and 97 samples from adults. While TP53 and CCND3 mutation frequencies are not age related, samples from pediatric patients showed a higher frequency of mutations in ID3, DDX3X, ARID1A and SMARCA4, while several genes such as BCL2 and YY1AP1 are almost exclusively mutated in adult patients. An unbiased analysis reveals a transition of the mutational profile between 25 and 40 years of age. Survival analysis in the pediatric cohort confirms that TP53 mutations are significantly associated with higher incidence of relapse (25 ± 4% versus 6 ± 2%, p-value 0.0002). This identifies a promising molecular marker for relapse incidence in pediatric BL which will be used in future clinical trials. |
| format | Online Article Text |
| id | pubmed-9259584 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-92595842022-07-08 Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age Burkhardt, Birgit Michgehl, Ulf Rohde, Jonas Erdmann, Tabea Berning, Philipp Reutter, Katrin Rohde, Marius Borkhardt, Arndt Burmeister, Thomas Dave, Sandeep Tzankov, Alexandar Dugas, Martin Sandmann, Sarah Fend, Falko Finger, Jasmin Mueller, Stephanie Gökbuget, Nicola Haferlach, Torsten Kern, Wolfgang Hartmann, Wolfgang Klapper, Wolfram Oschlies, Ilske Richter, Julia Kontny, Udo Lutz, Mathias Maecker-Kolhoff, Britta Ott, German Rosenwald, Andreas Siebert, Reiner von Stackelberg, Arend Strahm, Brigitte Woessmann, Wilhelm Zimmermann, Martin Zapukhlyak, Myroslav Grau, Michael Lenz, Georg Nat Commun Article While survival has improved for Burkitt lymphoma patients, potential differences in outcome between pediatric and adult patients remain unclear. In both age groups, survival remains poor at relapse. Therefore, we conducted a comparative study in a large pediatric cohort, including 191 cases and 97 samples from adults. While TP53 and CCND3 mutation frequencies are not age related, samples from pediatric patients showed a higher frequency of mutations in ID3, DDX3X, ARID1A and SMARCA4, while several genes such as BCL2 and YY1AP1 are almost exclusively mutated in adult patients. An unbiased analysis reveals a transition of the mutational profile between 25 and 40 years of age. Survival analysis in the pediatric cohort confirms that TP53 mutations are significantly associated with higher incidence of relapse (25 ± 4% versus 6 ± 2%, p-value 0.0002). This identifies a promising molecular marker for relapse incidence in pediatric BL which will be used in future clinical trials. Nature Publishing Group UK 2022-07-06 /pmc/articles/PMC9259584/ /pubmed/35794096 http://dx.doi.org/10.1038/s41467-022-31355-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Burkhardt, Birgit Michgehl, Ulf Rohde, Jonas Erdmann, Tabea Berning, Philipp Reutter, Katrin Rohde, Marius Borkhardt, Arndt Burmeister, Thomas Dave, Sandeep Tzankov, Alexandar Dugas, Martin Sandmann, Sarah Fend, Falko Finger, Jasmin Mueller, Stephanie Gökbuget, Nicola Haferlach, Torsten Kern, Wolfgang Hartmann, Wolfgang Klapper, Wolfram Oschlies, Ilske Richter, Julia Kontny, Udo Lutz, Mathias Maecker-Kolhoff, Britta Ott, German Rosenwald, Andreas Siebert, Reiner von Stackelberg, Arend Strahm, Brigitte Woessmann, Wilhelm Zimmermann, Martin Zapukhlyak, Myroslav Grau, Michael Lenz, Georg Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age |
| title | Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age |
| title_full | Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age |
| title_fullStr | Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age |
| title_full_unstemmed | Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age |
| title_short | Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age |
| title_sort | clinical relevance of molecular characteristics in burkitt lymphoma differs according to age |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259584/ https://www.ncbi.nlm.nih.gov/pubmed/35794096 http://dx.doi.org/10.1038/s41467-022-31355-8 |
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