REL-1017 (esmethadone; d-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats

REL-1017 (esmethadone, d-methadone) is the opioid-inactive d-isomer of racemic d,l-methadone. REL-1017 may exert antidepressant effects via uncompetitive N-methyl-d-aspartate receptor (NMDAR) channel block. As REL-1017 is expected to exert central nervous system activity, full characterization of it...

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Detalles Bibliográficos
Autores principales: Henningfield, Jack, Gauvin, David, Bifari, Francesco, Fant, Reginald, Shram, Megan, Buchhalter, August, Ashworth, Judy, Lanier, Ryan, Pappagallo, Marco, Inturrisi, Charles, Folli, Franco, Traversa, Sergio, Manfredi, Paolo L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259683/
https://www.ncbi.nlm.nih.gov/pubmed/35794162
http://dx.doi.org/10.1038/s41598-022-15055-3

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