Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression

Mitochondrial dynamics can regulate Major Histocompatibility Complex (MHC)-I antigen expression by cancer cells and their immunogenicity in mice and in patients with malignancies. A crucial role in the mitochondrial fragmentation connection with immunogenicity is played by the IRE1α-XBP-1s axis. XBP...

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Detalles Bibliográficos
Autores principales: Lei, Xinyuan, Lin, Hsinyu, Wang, Jieqi, Ou, Zhanpeng, Ruan, Yi, Sadagopan, Ananthan, Chen, Weixiong, Xie, Shule, Chen, Baisheng, Li, Qunxing, Wang, Jue, Lin, Huayue, Zhu, Xiaofeng, Yuan, Xiaoqing, Tian, Tian, Lv, Xiaobin, Fu, Sha, Zhu, Xiaorui, Zhou, Jian, Pan, Guokai, Xia, Xin, Tannous, Bakhos A., Ferrone, Soldano, Fan, Song, Li, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259736/
https://www.ncbi.nlm.nih.gov/pubmed/35794100
http://dx.doi.org/10.1038/s41467-022-31417-x

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