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Lustrous White Erosions Surrounded by an Erythematous Mucosa: A Novel Endoscopic Finding of Gastric Lesions in Patients with Wilson Disease

Wilson disease is an inherited copper metabolism disorder. We herein report a novel endoscopic finding in three men with Wilson disease. These patients underwent upper endoscopy due to gastrointestinal symptoms or during follow-up. In each case, endoscopy revealed lustrous white erosions surrounded...

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Autores principales: Kitagawa, Daiki, Ominami, Masaki, Taira, Koichi, Tanoue, Kojiro, Higashimori, Akira, Maruyama, Hirotsugu, Itani, Shigehiro, Nishida, Yu, Nadatani, Yuji, Fukunaga, Shusei, Otani, Koji, Hosomi, Shuhei, Tanaka, Fumio, Nagami, Yasuaki, Kamata, Noriko, Kuwae, Yuko, Watanabe, Toshio, Ohsawa, Masahiko, Fujiwara, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259810/
https://www.ncbi.nlm.nih.gov/pubmed/34866098
http://dx.doi.org/10.2169/internalmedicine.8076-21
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author Kitagawa, Daiki
Ominami, Masaki
Taira, Koichi
Tanoue, Kojiro
Higashimori, Akira
Maruyama, Hirotsugu
Itani, Shigehiro
Nishida, Yu
Nadatani, Yuji
Fukunaga, Shusei
Otani, Koji
Hosomi, Shuhei
Tanaka, Fumio
Nagami, Yasuaki
Kamata, Noriko
Kuwae, Yuko
Watanabe, Toshio
Ohsawa, Masahiko
Fujiwara, Yasuhiro
author_facet Kitagawa, Daiki
Ominami, Masaki
Taira, Koichi
Tanoue, Kojiro
Higashimori, Akira
Maruyama, Hirotsugu
Itani, Shigehiro
Nishida, Yu
Nadatani, Yuji
Fukunaga, Shusei
Otani, Koji
Hosomi, Shuhei
Tanaka, Fumio
Nagami, Yasuaki
Kamata, Noriko
Kuwae, Yuko
Watanabe, Toshio
Ohsawa, Masahiko
Fujiwara, Yasuhiro
author_sort Kitagawa, Daiki
collection PubMed
description Wilson disease is an inherited copper metabolism disorder. We herein report a novel endoscopic finding in three men with Wilson disease. These patients underwent upper endoscopy due to gastrointestinal symptoms or during follow-up. In each case, endoscopy revealed lustrous white erosions surrounded by an erythematous mucosa in the greater curvature of the gastric body. A biopsy of the lesions showed orcein-positive tissue, indicating copper deposition, in the interstitial stroma and fundic glands of the mucosa. All patients had been receiving treatment with zinc acetate. These endoscopic findings might have been related to the cytotoxicity of the accumulated copper and zinc acetate.
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spelling pubmed-92598102022-07-19 Lustrous White Erosions Surrounded by an Erythematous Mucosa: A Novel Endoscopic Finding of Gastric Lesions in Patients with Wilson Disease Kitagawa, Daiki Ominami, Masaki Taira, Koichi Tanoue, Kojiro Higashimori, Akira Maruyama, Hirotsugu Itani, Shigehiro Nishida, Yu Nadatani, Yuji Fukunaga, Shusei Otani, Koji Hosomi, Shuhei Tanaka, Fumio Nagami, Yasuaki Kamata, Noriko Kuwae, Yuko Watanabe, Toshio Ohsawa, Masahiko Fujiwara, Yasuhiro Intern Med Case Report Wilson disease is an inherited copper metabolism disorder. We herein report a novel endoscopic finding in three men with Wilson disease. These patients underwent upper endoscopy due to gastrointestinal symptoms or during follow-up. In each case, endoscopy revealed lustrous white erosions surrounded by an erythematous mucosa in the greater curvature of the gastric body. A biopsy of the lesions showed orcein-positive tissue, indicating copper deposition, in the interstitial stroma and fundic glands of the mucosa. All patients had been receiving treatment with zinc acetate. These endoscopic findings might have been related to the cytotoxicity of the accumulated copper and zinc acetate. The Japanese Society of Internal Medicine 2021-12-04 2022-06-15 /pmc/articles/PMC9259810/ /pubmed/34866098 http://dx.doi.org/10.2169/internalmedicine.8076-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kitagawa, Daiki
Ominami, Masaki
Taira, Koichi
Tanoue, Kojiro
Higashimori, Akira
Maruyama, Hirotsugu
Itani, Shigehiro
Nishida, Yu
Nadatani, Yuji
Fukunaga, Shusei
Otani, Koji
Hosomi, Shuhei
Tanaka, Fumio
Nagami, Yasuaki
Kamata, Noriko
Kuwae, Yuko
Watanabe, Toshio
Ohsawa, Masahiko
Fujiwara, Yasuhiro
Lustrous White Erosions Surrounded by an Erythematous Mucosa: A Novel Endoscopic Finding of Gastric Lesions in Patients with Wilson Disease
title Lustrous White Erosions Surrounded by an Erythematous Mucosa: A Novel Endoscopic Finding of Gastric Lesions in Patients with Wilson Disease
title_full Lustrous White Erosions Surrounded by an Erythematous Mucosa: A Novel Endoscopic Finding of Gastric Lesions in Patients with Wilson Disease
title_fullStr Lustrous White Erosions Surrounded by an Erythematous Mucosa: A Novel Endoscopic Finding of Gastric Lesions in Patients with Wilson Disease
title_full_unstemmed Lustrous White Erosions Surrounded by an Erythematous Mucosa: A Novel Endoscopic Finding of Gastric Lesions in Patients with Wilson Disease
title_short Lustrous White Erosions Surrounded by an Erythematous Mucosa: A Novel Endoscopic Finding of Gastric Lesions in Patients with Wilson Disease
title_sort lustrous white erosions surrounded by an erythematous mucosa: a novel endoscopic finding of gastric lesions in patients with wilson disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259810/
https://www.ncbi.nlm.nih.gov/pubmed/34866098
http://dx.doi.org/10.2169/internalmedicine.8076-21
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