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Associations of Uric Acid With Liver Steatosis and Fibrosis Applying Vibration Controlled Transient Elastography in the United States: A Nationwide Cross-Section Study
BACKGROUND AND OBJECTIVE: Serum uric acid (UA) is related to many metabolic diseases. However, the association of UA with liver diseases was not very clear. The objective of this study is to clarify the relationship of UA with liver steatosis and fibrosis. METHODS: This is a cross-sectional study of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259838/ https://www.ncbi.nlm.nih.gov/pubmed/35813625 http://dx.doi.org/10.3389/fendo.2022.930224 |
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author | Duan, Hualin Zhang, Rong Chen, Xingying Yu, Genfeng Song, Cheng Jiang, Yuqi He, Yajun Wan, Heng Shen, Jie |
author_facet | Duan, Hualin Zhang, Rong Chen, Xingying Yu, Genfeng Song, Cheng Jiang, Yuqi He, Yajun Wan, Heng Shen, Jie |
author_sort | Duan, Hualin |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Serum uric acid (UA) is related to many metabolic diseases. However, the association of UA with liver diseases was not very clear. The objective of this study is to clarify the relationship of UA with liver steatosis and fibrosis. METHODS: This is a cross-sectional study of 4364 people of National Health and Nutrition Examination Survey (NHANES) 2017-2018. Liver steatosis and fibrosis were assessed by controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) using Vibration-controlled transient elastography (VCTE). Linear and logistic regressions were performed. RESULTS: After adjusting for potential confounders, UA levels were associated with the prevalence of liver steatosis [OR=2.097 (95%CI: 1.245, 3.534)] and liver fibrosis [OR=2.983 (95%CI: 1.797, 4.952)]. Furthermore, the results were consistent in the subgroup analyses of males and females. CONCLUSIONS: UA levels were positively associated with the prevalence of liver steatosis and fibrosis. |
format | Online Article Text |
id | pubmed-9259838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92598382022-07-08 Associations of Uric Acid With Liver Steatosis and Fibrosis Applying Vibration Controlled Transient Elastography in the United States: A Nationwide Cross-Section Study Duan, Hualin Zhang, Rong Chen, Xingying Yu, Genfeng Song, Cheng Jiang, Yuqi He, Yajun Wan, Heng Shen, Jie Front Endocrinol (Lausanne) Endocrinology BACKGROUND AND OBJECTIVE: Serum uric acid (UA) is related to many metabolic diseases. However, the association of UA with liver diseases was not very clear. The objective of this study is to clarify the relationship of UA with liver steatosis and fibrosis. METHODS: This is a cross-sectional study of 4364 people of National Health and Nutrition Examination Survey (NHANES) 2017-2018. Liver steatosis and fibrosis were assessed by controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) using Vibration-controlled transient elastography (VCTE). Linear and logistic regressions were performed. RESULTS: After adjusting for potential confounders, UA levels were associated with the prevalence of liver steatosis [OR=2.097 (95%CI: 1.245, 3.534)] and liver fibrosis [OR=2.983 (95%CI: 1.797, 4.952)]. Furthermore, the results were consistent in the subgroup analyses of males and females. CONCLUSIONS: UA levels were positively associated with the prevalence of liver steatosis and fibrosis. Frontiers Media S.A. 2022-06-23 /pmc/articles/PMC9259838/ /pubmed/35813625 http://dx.doi.org/10.3389/fendo.2022.930224 Text en Copyright © 2022 Duan, Zhang, Chen, Yu, Song, Jiang, He, Wan and Shen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Duan, Hualin Zhang, Rong Chen, Xingying Yu, Genfeng Song, Cheng Jiang, Yuqi He, Yajun Wan, Heng Shen, Jie Associations of Uric Acid With Liver Steatosis and Fibrosis Applying Vibration Controlled Transient Elastography in the United States: A Nationwide Cross-Section Study |
title | Associations of Uric Acid With Liver Steatosis and Fibrosis Applying Vibration Controlled Transient Elastography in the United States: A Nationwide Cross-Section Study |
title_full | Associations of Uric Acid With Liver Steatosis and Fibrosis Applying Vibration Controlled Transient Elastography in the United States: A Nationwide Cross-Section Study |
title_fullStr | Associations of Uric Acid With Liver Steatosis and Fibrosis Applying Vibration Controlled Transient Elastography in the United States: A Nationwide Cross-Section Study |
title_full_unstemmed | Associations of Uric Acid With Liver Steatosis and Fibrosis Applying Vibration Controlled Transient Elastography in the United States: A Nationwide Cross-Section Study |
title_short | Associations of Uric Acid With Liver Steatosis and Fibrosis Applying Vibration Controlled Transient Elastography in the United States: A Nationwide Cross-Section Study |
title_sort | associations of uric acid with liver steatosis and fibrosis applying vibration controlled transient elastography in the united states: a nationwide cross-section study |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259838/ https://www.ncbi.nlm.nih.gov/pubmed/35813625 http://dx.doi.org/10.3389/fendo.2022.930224 |
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