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Embryological Characteristics of Human Oocytes With Agar-Like Zona Pellucida and Its Clinical Treatment Strategy

Zona pellucida (ZP) abnormalities are the cause of low fertility or infertility, agar-like ZP is more common in abnormal ZP. The purpose of this exploration is to systematically analyze the fertilization competence of agar-like ZP oocytes, the development characteristics of subsequent embryos as wel...

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Autores principales: Yang, Dandan, Yang, Han, Yang, Bo, Wang, Kaijuan, Zhu, Qi, Wang, Jing, Ding, Fangfang, Rao, Bihua, Xue, Rufeng, Peng, Jing, Wang, Qiushuang, Cao, Yunxia, Zou, Weiwei, Chen, Beili, Zhang, Zhiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259955/
https://www.ncbi.nlm.nih.gov/pubmed/35813655
http://dx.doi.org/10.3389/fendo.2022.859361
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author Yang, Dandan
Yang, Han
Yang, Bo
Wang, Kaijuan
Zhu, Qi
Wang, Jing
Ding, Fangfang
Rao, Bihua
Xue, Rufeng
Peng, Jing
Wang, Qiushuang
Cao, Yunxia
Zou, Weiwei
Chen, Beili
Zhang, Zhiguo
author_facet Yang, Dandan
Yang, Han
Yang, Bo
Wang, Kaijuan
Zhu, Qi
Wang, Jing
Ding, Fangfang
Rao, Bihua
Xue, Rufeng
Peng, Jing
Wang, Qiushuang
Cao, Yunxia
Zou, Weiwei
Chen, Beili
Zhang, Zhiguo
author_sort Yang, Dandan
collection PubMed
description Zona pellucida (ZP) abnormalities are the cause of low fertility or infertility, agar-like ZP is more common in abnormal ZP. The purpose of this exploration is to systematically analyze the fertilization competence of agar-like ZP oocytes, the development characteristics of subsequent embryos as well as the results of embryo transfer, aiming to explore effective clinical treatment strategies. A total of 58 patients with agar-like ZP were set as the case group and the control group involved 3866 patients, in which the patients’ oocytes presented normal ZP. BMI, basal hormone levels, and hormone levels were similar in both groups. The case patients suffered significantly longer infertility years than control (p<0.05), and most patients were diagnosed with pelvic inflammatory diseases. A distinct difference was observed in the structure of oocyte corona cumulus complexes between the two groups. The embryo development parameters, which include the rates of cleavage, high-quality embryo, blastocyst, and high-quality blastocyst in the case group were greatly lower than that in the control group (p<0.05). The rates of cumulative clinical pregnancy and live birth were comparable between the two groups. In the subsequent follow-up, thirty-four of the 58 patients receiving intracytoplasmic single sperm injection (ICSI) or early rescue ICSI (R-ICSI) treatment successfully gave birth to babies, and all of the newborns were with no neonatal defects. In addition, the fertilization rate of the R-ICSI group was significantly lower than that of the ICSI group (p<0.05). The occurrence of agar-like ZP impairs the development competence of human oocytes, however, the human oocytes with agar-like ZP can develop into healthy offspring, and an ICSI regimen is the optimal treatment strategy for them.
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spelling pubmed-92599552022-07-08 Embryological Characteristics of Human Oocytes With Agar-Like Zona Pellucida and Its Clinical Treatment Strategy Yang, Dandan Yang, Han Yang, Bo Wang, Kaijuan Zhu, Qi Wang, Jing Ding, Fangfang Rao, Bihua Xue, Rufeng Peng, Jing Wang, Qiushuang Cao, Yunxia Zou, Weiwei Chen, Beili Zhang, Zhiguo Front Endocrinol (Lausanne) Endocrinology Zona pellucida (ZP) abnormalities are the cause of low fertility or infertility, agar-like ZP is more common in abnormal ZP. The purpose of this exploration is to systematically analyze the fertilization competence of agar-like ZP oocytes, the development characteristics of subsequent embryos as well as the results of embryo transfer, aiming to explore effective clinical treatment strategies. A total of 58 patients with agar-like ZP were set as the case group and the control group involved 3866 patients, in which the patients’ oocytes presented normal ZP. BMI, basal hormone levels, and hormone levels were similar in both groups. The case patients suffered significantly longer infertility years than control (p<0.05), and most patients were diagnosed with pelvic inflammatory diseases. A distinct difference was observed in the structure of oocyte corona cumulus complexes between the two groups. The embryo development parameters, which include the rates of cleavage, high-quality embryo, blastocyst, and high-quality blastocyst in the case group were greatly lower than that in the control group (p<0.05). The rates of cumulative clinical pregnancy and live birth were comparable between the two groups. In the subsequent follow-up, thirty-four of the 58 patients receiving intracytoplasmic single sperm injection (ICSI) or early rescue ICSI (R-ICSI) treatment successfully gave birth to babies, and all of the newborns were with no neonatal defects. In addition, the fertilization rate of the R-ICSI group was significantly lower than that of the ICSI group (p<0.05). The occurrence of agar-like ZP impairs the development competence of human oocytes, however, the human oocytes with agar-like ZP can develop into healthy offspring, and an ICSI regimen is the optimal treatment strategy for them. Frontiers Media S.A. 2022-06-23 /pmc/articles/PMC9259955/ /pubmed/35813655 http://dx.doi.org/10.3389/fendo.2022.859361 Text en Copyright © 2022 Yang, Yang, Yang, Wang, Zhu, Wang, Ding, Rao, Xue, Peng, Wang, Cao, Zou, Chen and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Yang, Dandan
Yang, Han
Yang, Bo
Wang, Kaijuan
Zhu, Qi
Wang, Jing
Ding, Fangfang
Rao, Bihua
Xue, Rufeng
Peng, Jing
Wang, Qiushuang
Cao, Yunxia
Zou, Weiwei
Chen, Beili
Zhang, Zhiguo
Embryological Characteristics of Human Oocytes With Agar-Like Zona Pellucida and Its Clinical Treatment Strategy
title Embryological Characteristics of Human Oocytes With Agar-Like Zona Pellucida and Its Clinical Treatment Strategy
title_full Embryological Characteristics of Human Oocytes With Agar-Like Zona Pellucida and Its Clinical Treatment Strategy
title_fullStr Embryological Characteristics of Human Oocytes With Agar-Like Zona Pellucida and Its Clinical Treatment Strategy
title_full_unstemmed Embryological Characteristics of Human Oocytes With Agar-Like Zona Pellucida and Its Clinical Treatment Strategy
title_short Embryological Characteristics of Human Oocytes With Agar-Like Zona Pellucida and Its Clinical Treatment Strategy
title_sort embryological characteristics of human oocytes with agar-like zona pellucida and its clinical treatment strategy
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259955/
https://www.ncbi.nlm.nih.gov/pubmed/35813655
http://dx.doi.org/10.3389/fendo.2022.859361
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