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Automated design of CRISPR prime editors for 56,000 human pathogenic variants

Prime editors (PEs) are clustered regularly interspaced short palindromic repeats (CRISPR)-based genome engineering tools that can introduce precise base-pair edits. We developed an automated pipeline to correct (therapeutic editing) or introduce (disease modeling) human pathogenic variants from Cli...

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Detalles Bibliográficos
Autores principales:	Morris, John A., Rahman, Jahan A., Guo, Xinyi, Sanjana, Neville E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259959/ https://www.ncbi.nlm.nih.gov/pubmed/35814872 http://dx.doi.org/10.1016/j.isci.2021.103380

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