Cargando…

Systematic review of the effect of D-mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)

Several studies, reviews and meta-analyses have documented that D-mannose use lowers the risk of recurrent urinary tract infections (UTI), but its role in the treatment of UTI/cystitis-related symptoms is unclear. In particular, no systematic review has analyzed the role of treatment with D-mannose...

Descripción completa

Detalles Bibliográficos
Autores principales: Parazzini, Fabio, Ricci, Elena, Fedele, Francesco, Chiaffarino, Francesca, Esposito, Giovanna, Cipriani, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260159/
https://www.ncbi.nlm.nih.gov/pubmed/35815191
http://dx.doi.org/10.3892/br.2022.1552
_version_ 1784741959444725760
author Parazzini, Fabio
Ricci, Elena
Fedele, Francesco
Chiaffarino, Francesca
Esposito, Giovanna
Cipriani, Sonia
author_facet Parazzini, Fabio
Ricci, Elena
Fedele, Francesco
Chiaffarino, Francesca
Esposito, Giovanna
Cipriani, Sonia
author_sort Parazzini, Fabio
collection PubMed
description Several studies, reviews and meta-analyses have documented that D-mannose use lowers the risk of recurrent urinary tract infections (UTI), but its role in the treatment of UTI/cystitis-related symptoms is unclear. In particular, no systematic review has analyzed the role of treatment with D-mannose in acute UTI/cystitis. In this paper, we systematically reviewed the published data on the effect of D-mannose, alone or in association with other compounds, on the typical symptoms of UTI/cystitis. PubMed/Medline and EMBASE databases were searched, from 1990 to January 2022, using combinations of the following keywords: ‘urinary tract infections’, ‘cystalgia’, ‘recurrent next urinary tract infection’, ‘cystitis’, ‘mannose’, ‘mannoside’, ‘D-mannose’, ‘bacteriuria’, ‘pyuria’, ‘pyelocystitis’ with the appropriate Boolean modifiers (Limits: Human, English, full article). Studies were selected for the systematic review if they were clinical studies and reported original data, the number of patients using D-mannose alone or in association with other treatments, and the number of patients with symptoms of UTI/cystitis at trial entry and after the follow-up period. A total of seven studies were identified. D-mannose was given alone in two studies, and was associated with cranberry extract, Morinda citrifolia fruit extract, pomegranate extract, fructo-oligosaccharides, lactobacilli, and N-acetylcysteine in the others. All studies reported that symptoms decreased after treatment with D-mannose. Despite the limitations of the studies, the consistent results observed among all studies give support to the general findings that D-mannose may be useful in the treatment of UTI/cystitis symptoms.
format Online
Article
Text
id pubmed-9260159
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-92601592022-07-08 Systematic review of the effect of D-mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review) Parazzini, Fabio Ricci, Elena Fedele, Francesco Chiaffarino, Francesca Esposito, Giovanna Cipriani, Sonia Biomed Rep Review Several studies, reviews and meta-analyses have documented that D-mannose use lowers the risk of recurrent urinary tract infections (UTI), but its role in the treatment of UTI/cystitis-related symptoms is unclear. In particular, no systematic review has analyzed the role of treatment with D-mannose in acute UTI/cystitis. In this paper, we systematically reviewed the published data on the effect of D-mannose, alone or in association with other compounds, on the typical symptoms of UTI/cystitis. PubMed/Medline and EMBASE databases were searched, from 1990 to January 2022, using combinations of the following keywords: ‘urinary tract infections’, ‘cystalgia’, ‘recurrent next urinary tract infection’, ‘cystitis’, ‘mannose’, ‘mannoside’, ‘D-mannose’, ‘bacteriuria’, ‘pyuria’, ‘pyelocystitis’ with the appropriate Boolean modifiers (Limits: Human, English, full article). Studies were selected for the systematic review if they were clinical studies and reported original data, the number of patients using D-mannose alone or in association with other treatments, and the number of patients with symptoms of UTI/cystitis at trial entry and after the follow-up period. A total of seven studies were identified. D-mannose was given alone in two studies, and was associated with cranberry extract, Morinda citrifolia fruit extract, pomegranate extract, fructo-oligosaccharides, lactobacilli, and N-acetylcysteine in the others. All studies reported that symptoms decreased after treatment with D-mannose. Despite the limitations of the studies, the consistent results observed among all studies give support to the general findings that D-mannose may be useful in the treatment of UTI/cystitis symptoms. D.A. Spandidos 2022-06-15 /pmc/articles/PMC9260159/ /pubmed/35815191 http://dx.doi.org/10.3892/br.2022.1552 Text en Copyright: © Parazzini et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Parazzini, Fabio
Ricci, Elena
Fedele, Francesco
Chiaffarino, Francesca
Esposito, Giovanna
Cipriani, Sonia
Systematic review of the effect of D-mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)
title Systematic review of the effect of D-mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)
title_full Systematic review of the effect of D-mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)
title_fullStr Systematic review of the effect of D-mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)
title_full_unstemmed Systematic review of the effect of D-mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)
title_short Systematic review of the effect of D-mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)
title_sort systematic review of the effect of d-mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (review)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260159/
https://www.ncbi.nlm.nih.gov/pubmed/35815191
http://dx.doi.org/10.3892/br.2022.1552
work_keys_str_mv AT parazzinifabio systematicreviewoftheeffectofdmannosewithorwithoutotherdrugsinthetreatmentofsymptomsofurinarytractinfectionscystitisreview
AT riccielena systematicreviewoftheeffectofdmannosewithorwithoutotherdrugsinthetreatmentofsymptomsofurinarytractinfectionscystitisreview
AT fedelefrancesco systematicreviewoftheeffectofdmannosewithorwithoutotherdrugsinthetreatmentofsymptomsofurinarytractinfectionscystitisreview
AT chiaffarinofrancesca systematicreviewoftheeffectofdmannosewithorwithoutotherdrugsinthetreatmentofsymptomsofurinarytractinfectionscystitisreview
AT espositogiovanna systematicreviewoftheeffectofdmannosewithorwithoutotherdrugsinthetreatmentofsymptomsofurinarytractinfectionscystitisreview
AT ciprianisonia systematicreviewoftheeffectofdmannosewithorwithoutotherdrugsinthetreatmentofsymptomsofurinarytractinfectionscystitisreview