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Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia

The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes one of the rate‐limiting steps in de novo pyrimidine biosynthesis, a pathway that provides essential metabolic precursors for nucleic acids, glycoproteins, and phospholipids. DHODH inhibitors (DHODHi) are clinically used for aut...

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Detalles Bibliográficos
Autores principales:	So, Joan, Lewis, Alexander C, Smith, Lorey K, Stanley, Kym, Franich, Rheana, Yoannidis, David, Pijpers, Lizzy, Dominguez, Pilar, Hogg, Simon J, Vervoort, Stephin J, Brown, Fiona C, Johnstone, Ricky W, McDonald, Gabrielle, Ulanet, Danielle B, Murtie, Josh, Gruber, Emily, Kats, Lev M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260210/ https://www.ncbi.nlm.nih.gov/pubmed/35514210 http://dx.doi.org/10.15252/emmm.202115203

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