The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib

Low‐flow vascular malformations are congenital overgrowths composed of abnormal blood vessels potentially causing pain, bleeding and obstruction of different organs. These diseases are caused by oncogenic mutations in the endothelium, which result in overactivation of the PI3K/AKT pathway. Lack of r...

Descripción completa

Detalles Bibliográficos
Autores principales: Kobialka, Piotr, Sabata, Helena, Vilalta, Odena, Gouveia, Leonor, Angulo‐Urarte, Ana, Muixí, Laia, Zanoncello, Jasmina, Muñoz‐Aznar, Oscar, Olaciregui, Nagore G, Fanlo, Lucia, Esteve‐Codina, Anna, Lavarino, Cinzia, Javierre, Biola M, Celis, Veronica, Rovira, Carlota, López‐Fernández, Susana, Baselga, Eulàlia, Mora, Jaume, Castillo, Sandra D, Graupera, Mariona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260211/
https://www.ncbi.nlm.nih.gov/pubmed/35695059
http://dx.doi.org/10.15252/emmm.202115619

Ejemplares similares

Ejemplares similares