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Association of Dietary Vitamin K Intake With Cognition in the Elderly

Several previous studies discussed the association between vitamin K (VK) status and cognition. But the association between dietary VK consumption and cognitive performance in the elderly was not well understood. Therefore, we investigated the correlation between dietary VK intake and the cognition...

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Autores principales: Wang, Anni, Zhao, Meng, Luo, Jia, Zhang, Tianhao, Zhang, Dongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260313/
https://www.ncbi.nlm.nih.gov/pubmed/35811956
http://dx.doi.org/10.3389/fnut.2022.900887
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author Wang, Anni
Zhao, Meng
Luo, Jia
Zhang, Tianhao
Zhang, Dongfeng
author_facet Wang, Anni
Zhao, Meng
Luo, Jia
Zhang, Tianhao
Zhang, Dongfeng
author_sort Wang, Anni
collection PubMed
description Several previous studies discussed the association between vitamin K (VK) status and cognition. But the association between dietary VK consumption and cognitive performance in the elderly was not well understood. Therefore, we investigated the correlation between dietary VK intake and the cognition of the elderly. Our research used the data of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014. The dietary intake of VK was assessed by two 24-h dietary recalls. The cognitive function was measured in the survey of NHANES, including the Consortium to Establish a Registry for Alzheimer’s disease Word Learning subtest (CERAD W-L), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST). Logistic regression and restricted cubic spline models were applied to assess the relationship between dietary VK intake and cognition. Compared with the lowest dietary VK intake group, the multivariate-adjusted odds ratio (OR) [95% confidence interval (95% CI)] of low CERAD W-L score for the highest intake group was 0.39 (0.26–0.60), the multivariate-adjusted OR (95% CI) of low AFT score was 0.59 (0.38–0.92), and the multivariate-adjusted OR (95% CI) of low DSST score was 0.44 (0.29–0.65), respectively. There was an L-shaped dose–response relationship between dietary VK intake and low CERAD W-L score. There was a linear dose–response relationship between dietary VK intake and low AFT score, and there was also a linear dose–response relationship for the low DSST score. In addition, we also found a negative association between VK from vegetables and the risk of low CERAD W-L scores. Dietary VK intake and VK intake from vegetables were inversely related to the risk of low cognitive performance of the elderly.
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spelling pubmed-92603132022-07-08 Association of Dietary Vitamin K Intake With Cognition in the Elderly Wang, Anni Zhao, Meng Luo, Jia Zhang, Tianhao Zhang, Dongfeng Front Nutr Nutrition Several previous studies discussed the association between vitamin K (VK) status and cognition. But the association between dietary VK consumption and cognitive performance in the elderly was not well understood. Therefore, we investigated the correlation between dietary VK intake and the cognition of the elderly. Our research used the data of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014. The dietary intake of VK was assessed by two 24-h dietary recalls. The cognitive function was measured in the survey of NHANES, including the Consortium to Establish a Registry for Alzheimer’s disease Word Learning subtest (CERAD W-L), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST). Logistic regression and restricted cubic spline models were applied to assess the relationship between dietary VK intake and cognition. Compared with the lowest dietary VK intake group, the multivariate-adjusted odds ratio (OR) [95% confidence interval (95% CI)] of low CERAD W-L score for the highest intake group was 0.39 (0.26–0.60), the multivariate-adjusted OR (95% CI) of low AFT score was 0.59 (0.38–0.92), and the multivariate-adjusted OR (95% CI) of low DSST score was 0.44 (0.29–0.65), respectively. There was an L-shaped dose–response relationship between dietary VK intake and low CERAD W-L score. There was a linear dose–response relationship between dietary VK intake and low AFT score, and there was also a linear dose–response relationship for the low DSST score. In addition, we also found a negative association between VK from vegetables and the risk of low CERAD W-L scores. Dietary VK intake and VK intake from vegetables were inversely related to the risk of low cognitive performance of the elderly. Frontiers Media S.A. 2022-06-23 /pmc/articles/PMC9260313/ /pubmed/35811956 http://dx.doi.org/10.3389/fnut.2022.900887 Text en Copyright © 2022 Wang, Zhao, Luo, Zhang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Wang, Anni
Zhao, Meng
Luo, Jia
Zhang, Tianhao
Zhang, Dongfeng
Association of Dietary Vitamin K Intake With Cognition in the Elderly
title Association of Dietary Vitamin K Intake With Cognition in the Elderly
title_full Association of Dietary Vitamin K Intake With Cognition in the Elderly
title_fullStr Association of Dietary Vitamin K Intake With Cognition in the Elderly
title_full_unstemmed Association of Dietary Vitamin K Intake With Cognition in the Elderly
title_short Association of Dietary Vitamin K Intake With Cognition in the Elderly
title_sort association of dietary vitamin k intake with cognition in the elderly
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260313/
https://www.ncbi.nlm.nih.gov/pubmed/35811956
http://dx.doi.org/10.3389/fnut.2022.900887
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