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Relevance and Regulation of Alternative Splicing in Plant Heat Stress Response: Current Understanding and Future Directions

Alternative splicing (AS) is a major mechanism for gene expression in eukaryotes, increasing proteome diversity but also regulating transcriptome abundance. High temperatures have a strong impact on the splicing profile of many genes and therefore AS is considered as an integral part of heat stress...

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Autores principales: Rosenkranz, Remus R. E., Ullrich, Sarah, Löchli, Karin, Simm, Stefan, Fragkostefanakis, Sotirios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260394/
https://www.ncbi.nlm.nih.gov/pubmed/35812973
http://dx.doi.org/10.3389/fpls.2022.911277
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author Rosenkranz, Remus R. E.
Ullrich, Sarah
Löchli, Karin
Simm, Stefan
Fragkostefanakis, Sotirios
author_facet Rosenkranz, Remus R. E.
Ullrich, Sarah
Löchli, Karin
Simm, Stefan
Fragkostefanakis, Sotirios
author_sort Rosenkranz, Remus R. E.
collection PubMed
description Alternative splicing (AS) is a major mechanism for gene expression in eukaryotes, increasing proteome diversity but also regulating transcriptome abundance. High temperatures have a strong impact on the splicing profile of many genes and therefore AS is considered as an integral part of heat stress response. While many studies have established a detailed description of the diversity of the RNAome under heat stress in different plant species and stress regimes, little is known on the underlying mechanisms that control this temperature-sensitive process. AS is mainly regulated by the activity of splicing regulators. Changes in the abundance of these proteins through transcription and AS, post-translational modifications and interactions with exonic and intronic cis-elements and core elements of the spliceosomes modulate the outcome of pre-mRNA splicing. As a major part of pre-mRNAs are spliced co-transcriptionally, the chromatin environment along with the RNA polymerase II elongation play a major role in the regulation of pre-mRNA splicing under heat stress conditions. Despite its importance, our understanding on the regulation of heat stress sensitive AS in plants is scarce. In this review, we summarize the current status of knowledge on the regulation of AS in plants under heat stress conditions. We discuss possible implications of different pathways based on results from non-plant systems to provide a perspective for researchers who aim to elucidate the molecular basis of AS under high temperatures.
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spelling pubmed-92603942022-07-08 Relevance and Regulation of Alternative Splicing in Plant Heat Stress Response: Current Understanding and Future Directions Rosenkranz, Remus R. E. Ullrich, Sarah Löchli, Karin Simm, Stefan Fragkostefanakis, Sotirios Front Plant Sci Plant Science Alternative splicing (AS) is a major mechanism for gene expression in eukaryotes, increasing proteome diversity but also regulating transcriptome abundance. High temperatures have a strong impact on the splicing profile of many genes and therefore AS is considered as an integral part of heat stress response. While many studies have established a detailed description of the diversity of the RNAome under heat stress in different plant species and stress regimes, little is known on the underlying mechanisms that control this temperature-sensitive process. AS is mainly regulated by the activity of splicing regulators. Changes in the abundance of these proteins through transcription and AS, post-translational modifications and interactions with exonic and intronic cis-elements and core elements of the spliceosomes modulate the outcome of pre-mRNA splicing. As a major part of pre-mRNAs are spliced co-transcriptionally, the chromatin environment along with the RNA polymerase II elongation play a major role in the regulation of pre-mRNA splicing under heat stress conditions. Despite its importance, our understanding on the regulation of heat stress sensitive AS in plants is scarce. In this review, we summarize the current status of knowledge on the regulation of AS in plants under heat stress conditions. We discuss possible implications of different pathways based on results from non-plant systems to provide a perspective for researchers who aim to elucidate the molecular basis of AS under high temperatures. Frontiers Media S.A. 2022-06-23 /pmc/articles/PMC9260394/ /pubmed/35812973 http://dx.doi.org/10.3389/fpls.2022.911277 Text en Copyright © 2022 Rosenkranz, Ullrich, Löchli, Simm and Fragkostefanakis. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Rosenkranz, Remus R. E.
Ullrich, Sarah
Löchli, Karin
Simm, Stefan
Fragkostefanakis, Sotirios
Relevance and Regulation of Alternative Splicing in Plant Heat Stress Response: Current Understanding and Future Directions
title Relevance and Regulation of Alternative Splicing in Plant Heat Stress Response: Current Understanding and Future Directions
title_full Relevance and Regulation of Alternative Splicing in Plant Heat Stress Response: Current Understanding and Future Directions
title_fullStr Relevance and Regulation of Alternative Splicing in Plant Heat Stress Response: Current Understanding and Future Directions
title_full_unstemmed Relevance and Regulation of Alternative Splicing in Plant Heat Stress Response: Current Understanding and Future Directions
title_short Relevance and Regulation of Alternative Splicing in Plant Heat Stress Response: Current Understanding and Future Directions
title_sort relevance and regulation of alternative splicing in plant heat stress response: current understanding and future directions
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260394/
https://www.ncbi.nlm.nih.gov/pubmed/35812973
http://dx.doi.org/10.3389/fpls.2022.911277
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