Rationale and design of a multicenter, single-group, open-label trial aiming at investigating the effectiveness of elobixibat for loss of defecation desire in patients with chronic constipation

BACKGROUND: Approximately 60% of patients with chronic constipation (CC) have a significantly higher rate of loss of defecation desire (LODD). Bile acids are expected to have a restorative effect on defecation desire (DD) because they lower the rectal sensory threshold, which is an objective index o...

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Detalles Bibliográficos
Autores principales: Yamamoto, Atsushi, Kessoku, Takaomi, Tanaka, Kosuke, Takahashi, Kota, Kasai, Yuki, Ozaki, Anna, Iwaki, Michihiro, Kobayashi, Takashi, Yoshihara, Tsutomu, Misawa, Noboru, Ohkuma, Kanji, Fuyuki, Akiko, Higurashi, Takuma, Hosono, Kunihiro, Yoneda, Masato, Iwasaki, Tomoyuki, Kurihashi, Takeo, Nakatogawa, Machiko, Suzuki, Ayao, Taguri, Masataka, Oyamada, Shunsuke, Ariyoshi, Keisuke, Kobayashi, Noritoshi, Ichikawa, Yasushi, Nakajima, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260435/
https://www.ncbi.nlm.nih.gov/pubmed/35812817
http://dx.doi.org/10.1016/j.conctc.2022.100958

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