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Established and Emerging Therapies in Acute Spinal Cord Injury
Acute spinal cord injury (SCI) is devastating for patients and their caretakers and has an annual incidence of 20–50 per million people. Following initial assessment with appropriate physical examination and imaging, patients who are deemed surgical candidates should undergo decompression with stabi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Spinal Neurosurgery Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260540/ https://www.ncbi.nlm.nih.gov/pubmed/35793931 http://dx.doi.org/10.14245/ns.2244176.088 |
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author | Gadot, Ron Smith, David N. Prablek, Marc Grochmal, Joey K. Fuentes, Alfonso Ropper, Alexander E. |
author_facet | Gadot, Ron Smith, David N. Prablek, Marc Grochmal, Joey K. Fuentes, Alfonso Ropper, Alexander E. |
author_sort | Gadot, Ron |
collection | PubMed |
description | Acute spinal cord injury (SCI) is devastating for patients and their caretakers and has an annual incidence of 20–50 per million people. Following initial assessment with appropriate physical examination and imaging, patients who are deemed surgical candidates should undergo decompression with stabilization. Earlier intervention can improve neurological recovery in the post-operative period while allowing earlier mobilization. Optimized medical management is paramount to improve outcomes. Emerging strategies for managing SCI in the acute period stem from an evolving understanding of the pathophysiology of the injury. General areas of focus include ischemia prevention, reduction of secondary injury due to inflammation, modulation of the cytotoxic and immune response, and promotion of cellular regeneration. In this article, we review established, emerging, and novel experimental therapies. Continued translational research on these methods will improve the feasibility of bench-to-bedside innovations in treating patients with acute SCI. |
format | Online Article Text |
id | pubmed-9260540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Spinal Neurosurgery Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-92605402022-07-20 Established and Emerging Therapies in Acute Spinal Cord Injury Gadot, Ron Smith, David N. Prablek, Marc Grochmal, Joey K. Fuentes, Alfonso Ropper, Alexander E. Neurospine Review Article Acute spinal cord injury (SCI) is devastating for patients and their caretakers and has an annual incidence of 20–50 per million people. Following initial assessment with appropriate physical examination and imaging, patients who are deemed surgical candidates should undergo decompression with stabilization. Earlier intervention can improve neurological recovery in the post-operative period while allowing earlier mobilization. Optimized medical management is paramount to improve outcomes. Emerging strategies for managing SCI in the acute period stem from an evolving understanding of the pathophysiology of the injury. General areas of focus include ischemia prevention, reduction of secondary injury due to inflammation, modulation of the cytotoxic and immune response, and promotion of cellular regeneration. In this article, we review established, emerging, and novel experimental therapies. Continued translational research on these methods will improve the feasibility of bench-to-bedside innovations in treating patients with acute SCI. Korean Spinal Neurosurgery Society 2022-06 2022-06-30 /pmc/articles/PMC9260540/ /pubmed/35793931 http://dx.doi.org/10.14245/ns.2244176.088 Text en Copyright © 2022 by the Korean Spinal Neurosurgery Society https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gadot, Ron Smith, David N. Prablek, Marc Grochmal, Joey K. Fuentes, Alfonso Ropper, Alexander E. Established and Emerging Therapies in Acute Spinal Cord Injury |
title | Established and Emerging Therapies in Acute Spinal Cord Injury |
title_full | Established and Emerging Therapies in Acute Spinal Cord Injury |
title_fullStr | Established and Emerging Therapies in Acute Spinal Cord Injury |
title_full_unstemmed | Established and Emerging Therapies in Acute Spinal Cord Injury |
title_short | Established and Emerging Therapies in Acute Spinal Cord Injury |
title_sort | established and emerging therapies in acute spinal cord injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260540/ https://www.ncbi.nlm.nih.gov/pubmed/35793931 http://dx.doi.org/10.14245/ns.2244176.088 |
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