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Association between thyroid hormones and skeletal muscle and bone in euthyroid type 2 diabetes patients

BACKGROUND: The impact of thyroid hormones within their normal ranges on skeletal muscle and bone in patients with type 2 diabetes mellitus (T2DM) remains unknown. The purpose of this study was to investigate the relationships of thyroid hormones with muscle and bone in euthyroid patients with T2DM....

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Autores principales: Fang, Ling-na, Zhong, Shao, Ma, Dan, Hao, Yan-min, Gao, Yan, Zhang, Li, Shen, Li-wen, Sun, He-ping, Lu, Ke, Li, Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260573/
https://www.ncbi.nlm.nih.gov/pubmed/35813190
http://dx.doi.org/10.1177/20406223221107848
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author Fang, Ling-na
Zhong, Shao
Ma, Dan
Hao, Yan-min
Gao, Yan
Zhang, Li
Shen, Li-wen
Sun, He-ping
Lu, Ke
Li, Chong
author_facet Fang, Ling-na
Zhong, Shao
Ma, Dan
Hao, Yan-min
Gao, Yan
Zhang, Li
Shen, Li-wen
Sun, He-ping
Lu, Ke
Li, Chong
author_sort Fang, Ling-na
collection PubMed
description BACKGROUND: The impact of thyroid hormones within their normal ranges on skeletal muscle and bone in patients with type 2 diabetes mellitus (T2DM) remains unknown. The purpose of this study was to investigate the relationships of thyroid hormones with muscle and bone in euthyroid patients with T2DM. METHODS: This cross-sectional study included 344 euthyroid T2DM patients. Muscle mass and bone mineral density were measured by dual-energy X-ray absorptiometry. The levels of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxin (FT4) were measured by electrochemiluminescence immunoassay. RESULTS: The results revealed that FT3 was positively correlated with body mass index (BMI) in male patients after age correction. In men, FT4 was negatively correlated with body weight, BMI, total muscle mass, appendicular skeletal muscle mass (ASM), and ASM index (ASMI), while FT3/FT4 was positively correlated with body weight, BMI, total muscle mass, ASM, and ASMI after age correction. In women, FT4 was negatively correlated with ASM and ASMI, while FT3/FT4 was positively correlated with ASM and ASMI after age correction. FT3/FT4 was significantly lower in men with low muscle mass than in those with normal muscle mass. The age-adjusted odds for incident low muscle mass comparing the lowest and highest FT3/FT4 increased in men. CONCLUSIONS: FT3/FT4 was positively correlated with ASM and ASMI in both men and women. Therefore, FT3/FT4 may be a parameter indicative of low muscle mass in euthyroid men with T2DM.
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spelling pubmed-92605732022-07-08 Association between thyroid hormones and skeletal muscle and bone in euthyroid type 2 diabetes patients Fang, Ling-na Zhong, Shao Ma, Dan Hao, Yan-min Gao, Yan Zhang, Li Shen, Li-wen Sun, He-ping Lu, Ke Li, Chong Ther Adv Chronic Dis Original Research BACKGROUND: The impact of thyroid hormones within their normal ranges on skeletal muscle and bone in patients with type 2 diabetes mellitus (T2DM) remains unknown. The purpose of this study was to investigate the relationships of thyroid hormones with muscle and bone in euthyroid patients with T2DM. METHODS: This cross-sectional study included 344 euthyroid T2DM patients. Muscle mass and bone mineral density were measured by dual-energy X-ray absorptiometry. The levels of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxin (FT4) were measured by electrochemiluminescence immunoassay. RESULTS: The results revealed that FT3 was positively correlated with body mass index (BMI) in male patients after age correction. In men, FT4 was negatively correlated with body weight, BMI, total muscle mass, appendicular skeletal muscle mass (ASM), and ASM index (ASMI), while FT3/FT4 was positively correlated with body weight, BMI, total muscle mass, ASM, and ASMI after age correction. In women, FT4 was negatively correlated with ASM and ASMI, while FT3/FT4 was positively correlated with ASM and ASMI after age correction. FT3/FT4 was significantly lower in men with low muscle mass than in those with normal muscle mass. The age-adjusted odds for incident low muscle mass comparing the lowest and highest FT3/FT4 increased in men. CONCLUSIONS: FT3/FT4 was positively correlated with ASM and ASMI in both men and women. Therefore, FT3/FT4 may be a parameter indicative of low muscle mass in euthyroid men with T2DM. SAGE Publications 2022-07-04 /pmc/articles/PMC9260573/ /pubmed/35813190 http://dx.doi.org/10.1177/20406223221107848 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Fang, Ling-na
Zhong, Shao
Ma, Dan
Hao, Yan-min
Gao, Yan
Zhang, Li
Shen, Li-wen
Sun, He-ping
Lu, Ke
Li, Chong
Association between thyroid hormones and skeletal muscle and bone in euthyroid type 2 diabetes patients
title Association between thyroid hormones and skeletal muscle and bone in euthyroid type 2 diabetes patients
title_full Association between thyroid hormones and skeletal muscle and bone in euthyroid type 2 diabetes patients
title_fullStr Association between thyroid hormones and skeletal muscle and bone in euthyroid type 2 diabetes patients
title_full_unstemmed Association between thyroid hormones and skeletal muscle and bone in euthyroid type 2 diabetes patients
title_short Association between thyroid hormones and skeletal muscle and bone in euthyroid type 2 diabetes patients
title_sort association between thyroid hormones and skeletal muscle and bone in euthyroid type 2 diabetes patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260573/
https://www.ncbi.nlm.nih.gov/pubmed/35813190
http://dx.doi.org/10.1177/20406223221107848
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