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ExlA: A New Contributor to Pseudomonas aeruginosa Virulence

ExlA (also called exolysin) is a recently discovered virulence factor secreted by a subset of Pseudomonas aeruginosa strains in which a type 3 secretion system is lacking. exlA-positive strains were identified worldwide in the clinic, causing several types of infectious diseases, and were detected i...

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Autor principal: Huber, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260685/
https://www.ncbi.nlm.nih.gov/pubmed/35811671
http://dx.doi.org/10.3389/fcimb.2022.929150
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author Huber, Philippe
author_facet Huber, Philippe
author_sort Huber, Philippe
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description ExlA (also called exolysin) is a recently discovered virulence factor secreted by a subset of Pseudomonas aeruginosa strains in which a type 3 secretion system is lacking. exlA-positive strains were identified worldwide in the clinic, causing several types of infectious diseases, and were detected in various locations in the environment. ExlA possesses pore-forming activity and is cytolytic for most human cell types. It belongs to a class of poorly characterized bacterial toxins, sharing a similar protein domain organization and a common secretion pathway. This review summarizes the recent findings regarding ExlA synthesis, its secretion pathway, and its toxic behavior for host cells.
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spelling pubmed-92606852022-07-08 ExlA: A New Contributor to Pseudomonas aeruginosa Virulence Huber, Philippe Front Cell Infect Microbiol Cellular and Infection Microbiology ExlA (also called exolysin) is a recently discovered virulence factor secreted by a subset of Pseudomonas aeruginosa strains in which a type 3 secretion system is lacking. exlA-positive strains were identified worldwide in the clinic, causing several types of infectious diseases, and were detected in various locations in the environment. ExlA possesses pore-forming activity and is cytolytic for most human cell types. It belongs to a class of poorly characterized bacterial toxins, sharing a similar protein domain organization and a common secretion pathway. This review summarizes the recent findings regarding ExlA synthesis, its secretion pathway, and its toxic behavior for host cells. Frontiers Media S.A. 2022-06-23 /pmc/articles/PMC9260685/ /pubmed/35811671 http://dx.doi.org/10.3389/fcimb.2022.929150 Text en Copyright © 2022 Huber https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Huber, Philippe
ExlA: A New Contributor to Pseudomonas aeruginosa Virulence
title ExlA: A New Contributor to Pseudomonas aeruginosa Virulence
title_full ExlA: A New Contributor to Pseudomonas aeruginosa Virulence
title_fullStr ExlA: A New Contributor to Pseudomonas aeruginosa Virulence
title_full_unstemmed ExlA: A New Contributor to Pseudomonas aeruginosa Virulence
title_short ExlA: A New Contributor to Pseudomonas aeruginosa Virulence
title_sort exla: a new contributor to pseudomonas aeruginosa virulence
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260685/
https://www.ncbi.nlm.nih.gov/pubmed/35811671
http://dx.doi.org/10.3389/fcimb.2022.929150
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