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ExlA: A New Contributor to Pseudomonas aeruginosa Virulence
ExlA (also called exolysin) is a recently discovered virulence factor secreted by a subset of Pseudomonas aeruginosa strains in which a type 3 secretion system is lacking. exlA-positive strains were identified worldwide in the clinic, causing several types of infectious diseases, and were detected i...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260685/ https://www.ncbi.nlm.nih.gov/pubmed/35811671 http://dx.doi.org/10.3389/fcimb.2022.929150 |
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author | Huber, Philippe |
author_facet | Huber, Philippe |
author_sort | Huber, Philippe |
collection | PubMed |
description | ExlA (also called exolysin) is a recently discovered virulence factor secreted by a subset of Pseudomonas aeruginosa strains in which a type 3 secretion system is lacking. exlA-positive strains were identified worldwide in the clinic, causing several types of infectious diseases, and were detected in various locations in the environment. ExlA possesses pore-forming activity and is cytolytic for most human cell types. It belongs to a class of poorly characterized bacterial toxins, sharing a similar protein domain organization and a common secretion pathway. This review summarizes the recent findings regarding ExlA synthesis, its secretion pathway, and its toxic behavior for host cells. |
format | Online Article Text |
id | pubmed-9260685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92606852022-07-08 ExlA: A New Contributor to Pseudomonas aeruginosa Virulence Huber, Philippe Front Cell Infect Microbiol Cellular and Infection Microbiology ExlA (also called exolysin) is a recently discovered virulence factor secreted by a subset of Pseudomonas aeruginosa strains in which a type 3 secretion system is lacking. exlA-positive strains were identified worldwide in the clinic, causing several types of infectious diseases, and were detected in various locations in the environment. ExlA possesses pore-forming activity and is cytolytic for most human cell types. It belongs to a class of poorly characterized bacterial toxins, sharing a similar protein domain organization and a common secretion pathway. This review summarizes the recent findings regarding ExlA synthesis, its secretion pathway, and its toxic behavior for host cells. Frontiers Media S.A. 2022-06-23 /pmc/articles/PMC9260685/ /pubmed/35811671 http://dx.doi.org/10.3389/fcimb.2022.929150 Text en Copyright © 2022 Huber https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Huber, Philippe ExlA: A New Contributor to Pseudomonas aeruginosa Virulence |
title | ExlA: A New Contributor to Pseudomonas aeruginosa Virulence |
title_full | ExlA: A New Contributor to Pseudomonas aeruginosa Virulence |
title_fullStr | ExlA: A New Contributor to Pseudomonas aeruginosa Virulence |
title_full_unstemmed | ExlA: A New Contributor to Pseudomonas aeruginosa Virulence |
title_short | ExlA: A New Contributor to Pseudomonas aeruginosa Virulence |
title_sort | exla: a new contributor to pseudomonas aeruginosa virulence |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260685/ https://www.ncbi.nlm.nih.gov/pubmed/35811671 http://dx.doi.org/10.3389/fcimb.2022.929150 |
work_keys_str_mv | AT huberphilippe exlaanewcontributortopseudomonasaeruginosavirulence |