Cargando…

Bacterial Enoyl-Reductases: The Ever-Growing List of Fabs, Their Mechanisms and Inhibition

Enoyl-ACP reductases (ENRs) are enzymes that catalyze the last step of the elongation cycle during fatty acid synthesis. In recent years, new bacterial ENR types were discovered, some of them with structures and mechanisms that differ from the canonical bacterial FabI enzymes. Here, we briefly revie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hopf, Fernanda S. M., Roth, Candida D., de Souza, Eduardo V., Galina, Luiza, Czeczot, Alexia M., Machado, Pablo, Basso, Luiz A., Bizarro, Cristiano V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260719/ https://www.ncbi.nlm.nih.gov/pubmed/35814645 http://dx.doi.org/10.3389/fmicb.2022.891610

Ejemplares similares

Determination of the Crystal Structure and Active Residues of FabV, the Enoyl-ACP Reductase from Xanthomonas oryzae
por: Li, He, et al.
Publicado: (2011)

Functional Characterization of Triclosan-Resistant Enoyl-acyl-carrier Protein Reductase (FabV) in Pseudomonas aeruginosa
por: Huang, Yong-Heng, et al.
Publicado: (2016)

Observed crowding effects on Mycobacterium tuberculosis 2-trans-enoyl-ACP (CoA) reductase enzyme activity are not due to excluded volume only
por: Rotta, Mariane, et al.
Publicado: (2017)

Pharmacophore and Molecular Docking Guided 3D-QSAR Study of Bacterial Enoyl-ACP Reductase (FabI) Inhibitors
por: Lu, Xiaoyun, et al.
Publicado: (2012)

Correlating drug–target kinetics and in vivo pharmacodynamics: long residence time inhibitors of the FabI enoyl-ACP reductase
por: Daryaee, Fereidoon, et al.
Publicado: (2016)

Evaluation of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase (DAHPS) as a Vulnerable Target in Mycobacterium tuberculosis
por: Galina, Luiza, et al.
Publicado: (2022)

1233. Identification of Novel Inhibitors of Clostridioides difficile Enoyl-Reductase II (FabK) by High-Throughput Virtual and Experimental Screening
por: Wahrmund, Rebecca D, et al.
Publicado: (2020)

Identification of potential inhibitors of Mycobacterium tuberculosis shikimate kinase: molecular docking, in silico toxicity and in vitro experiments
por: Freitas de Freitas, Talita, et al.
Publicado: (2022)

In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) Inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy
por: Dureja, Chetna, et al.
Publicado: (2023)

8-Mercaptoguanine-based inhibitors of Mycobacterium tuberculosis dihydroneopterin aldolase: synthesis, in vitro inhibition and docking studies
por: Czeczot, Alexia de Matos, et al.
Publicado: (2021)

Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase
por: Muench, Stephen P., et al.
Publicado: (2006)

Enzyme Mechanism and Slow-Onset Inhibition of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase by an Inorganic Complex
por: de Medeiros, Patrícia Soares de Maria, et al.
Publicado: (2011)

Pyrrolyl Pyrazoline Carbaldehydes as Enoyl-ACP Reductase Inhibitors: Design, Synthesis and Antitubercular Activity
por: Dixit, Sheshagiri R., et al.
Publicado: (2017)

Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme
por: Martinelli, Leonardo K. B., et al.
Publicado: (2017)

Evaluation of Enoyl-Acyl Carrier Protein Reductase Inhibitors as Pseudomonas aeruginosa Quorum-Quenching Reagents
por: Yang, Liang, et al.
Publicado: (2010)

Unsaturated fatty acid synthesis in Enterococcus faecalis requires a specific enoyl‐ACP reductase
por: Dong, Huijuan, et al.
Publicado: (2022)

Structure-based identification of novel inhibitors targeting the enoyl-ACP reductase enzyme of Acinetobacter baumannii
por: Khan, Shama, et al.
Publicado: (2023)

Identification of potential inhibitor targeting enoyl-acyl carrier protein reductase (InhA) in Mycobacterium tuberculosis: a computational approach
por: Shanthi, V., et al.
Publicado: (2013)

The Two Functional Enoyl-Acyl Carrier Protein Reductases of Enterococcus faecalis Do Not Mediate Triclosan Resistance
por: Zhu, Lei, et al.
Publicado: (2013)

Four amino acids define the CO(2) binding pocket of enoyl-CoA carboxylases/reductases
por: Stoffel, Gabriele M. M., et al.
Publicado: (2019)

The Ever-Growing Cost of Hospital Construction
Publicado: (1899)

The Ever-Growing Puzzle of Asynchronous Release
por: Rozov, Andrei, et al.
Publicado: (2019)

Adverse Events with Amiodarone—Will the List Ever End?
por: Reiffel, James A.
Publicado: (2018)

Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase: Enoyl Reductase and β-Ketoacyl Reductase Catalytic Domains
por: John, Arun, et al.
Publicado: (2015)

Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents
por: Muench, Stephen P., et al.
Publicado: (2007)

QSAR and Molecular Docking Studies of Oxadiazole-Ligated Pyrrole Derivatives as Enoyl-ACP (CoA) Reductase Inhibitors
por: Asgaonkar, Kalyani D., et al.
Publicado: (2014)

A Structural and Energetic Model for the Slow-Onset Inhibition of the Mycobacterium tuberculosis Enoyl-ACP Reductase InhA
por: Li, Huei-Jiun, et al.
Publicado: (2014)

InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis
por: Vögeli, Bastian, et al.
Publicado: (2018)

In Silico Repositioning of Cannabigerol as a Novel Inhibitor of the Enoyl Acyl Carrier Protein (ACP) Reductase (InhA)
por: Pinzi, Luca, et al.
Publicado: (2019)

The ever-growing complexity of the mitochondrial fission machinery
por: Pagliuso, Alessandro, et al.
Publicado: (2017)

A Novel Cytosolic Isoform of Mitochondrial Trans-2-Enoyl-CoA Reductase Enhances Peroxisome Proliferator-Activated Receptor α Activity
por: Kim, Dong-Gyu, et al.
Publicado: (2014)

Triclosan Resistome from Metagenome Reveals Diverse Enoyl Acyl Carrier Protein Reductases and Selective Enrichment of Triclosan Resistance Genes
por: Khan, Raees, et al.
Publicado: (2016)

ECERIFERUM 10 Encoding an Enoyl-CoA Reductase Plays a Crucial Role in Osmotolerance and Cuticular Wax Loading in Arabidopsis
por: Fukuda, Norika, et al.
Publicado: (2022)

Mycobacterium tuberculosis Shikimate Pathway Enzymes as Targets for the Rational Design of Anti-Tuberculosis Drugs
por: Nunes, José E. S., et al.
Publicado: (2020)

Novel trans-2,3-enoyl-CoA reductase–like variant associated with catecholaminergic polymorphic ventricular tachycardia type 3
por: Charafeddine, Fatme, et al.
Publicado: (2022)

The Elderly Population in Iran: An Ever Growing Concern in the Health System
por: Noroozian, Maryam
Publicado: (2012)

Demand versus supply in intensive care: an ever-growing problem
por: Tanaka Gutiez, M, et al.
Publicado: (2014)

Microbiome Associated with the Mycangia of Female and Male Adults of the Ambrosia Beetle Platypus cylindrus Fab. (Coleoptera: Curculionidae)
por: Nones, Stefano, et al.
Publicado: (2021)

Computer-Aided Design of Orally Bioavailable Pyrrolidine Carboxamide Inhibitors of Enoyl-Acyl Carrier Protein Reductase of Mycobacterium tuberculosis with Favorable Pharmacokinetic Profiles
por: Kouassi, Affiba Florance, et al.
Publicado: (2015)

Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming
por: Roberts, Douglas M., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_g65gh48l9r4n0o5805eh2coh78