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Pathological complete response to immune checkpoint inhibitor in patients with colorectal cancer liver metastases harboring POLE exonuclease domain mutation

Patients with polymerase epsilon (POLE) exonuclease domain mutation (EDM) exhibits distinct clinical characteristics and extremely high tumor mutation burden (TMB). There is a paucity of data on the therapeutic efficacy of immune checkpoint inhibitors (ICIs) for the treatment of colorectal cancer li...

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Detalles Bibliográficos
Autores principales:	Wen, Lei, Chen, Zhigang, Ji, Xiaomeng, Fong, William Pat, Shao, Qiong, Ren, Chao, Cai, Yanyu, Li, Binkui, Yuan, Yunfei, Wang, Deshen, Li, Yuhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Immunotherapy Biomarkers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260839/ https://www.ncbi.nlm.nih.gov/pubmed/35793867 http://dx.doi.org/10.1136/jitc-2022-004487

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