Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody

BACKGROUND: Understanding the mechanisms of non-T cell inflamed tumor microenvironment (TME) and their modulation are important to improve cancer immunotherapies such as immune checkpoint inhibitors. The involvement of various immunometabolisms has recently been indicated in the formation of immunos...

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Detalles Bibliográficos
Autores principales: Katoh, Yuki, Yaguchi, Tomonori, Kubo, Akiko, Iwata, Takashi, Morii, Kenji, Kato, Daiki, Ohta, Shigeki, Satomi, Ryosuke, Yamamoto, Yasuhiro, Oyamada, Yoshitaka, Ouchi, Kota, Takahashi, Shin, Ishioka, Chikashi, Matoba, Ryo, Suematsu, Makoto, Kawakami, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260842/
https://www.ncbi.nlm.nih.gov/pubmed/35793868
http://dx.doi.org/10.1136/jitc-2022-004616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260842/
https://www.ncbi.nlm.nih.gov/pubmed/35793868
http://dx.doi.org/10.1136/jitc-2022-004616

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