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Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents

Muscular strength, assessed by handgrip, is a risk indicator for psychiatric disorders, including psychosis. However, the biological mechanisms underlying this association remain unclear. Since advanced glycation end products (AGEs) play a key role in skeletal muscle underdevelopment and psychosis,...

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Autores principales: Suzuki, Kazuhiro, Yamasaki, Syudo, Miyashita, Mitsuhiro, Ando, Shuntaro, Toriumi, Kazuya, Yoshikawa, Akane, Nakanishi, Miharu, Morimoto, Yuko, Kanata, Sho, Fujikawa, Shinya, Endo, Kaori, Koike, Shinsuke, Usami, Satoshi, Itokawa, Masanari, Washizuka, Shinsuke, Hiraiwa-Hasegawa, Mariko, Meltzer, Herbert Y., Kasai, Kiyoto, Nishida, Atsushi, Arai, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261085/
https://www.ncbi.nlm.nih.gov/pubmed/35853893
http://dx.doi.org/10.1038/s41537-022-00249-5
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author Suzuki, Kazuhiro
Yamasaki, Syudo
Miyashita, Mitsuhiro
Ando, Shuntaro
Toriumi, Kazuya
Yoshikawa, Akane
Nakanishi, Miharu
Morimoto, Yuko
Kanata, Sho
Fujikawa, Shinya
Endo, Kaori
Koike, Shinsuke
Usami, Satoshi
Itokawa, Masanari
Washizuka, Shinsuke
Hiraiwa-Hasegawa, Mariko
Meltzer, Herbert Y.
Kasai, Kiyoto
Nishida, Atsushi
Arai, Makoto
author_facet Suzuki, Kazuhiro
Yamasaki, Syudo
Miyashita, Mitsuhiro
Ando, Shuntaro
Toriumi, Kazuya
Yoshikawa, Akane
Nakanishi, Miharu
Morimoto, Yuko
Kanata, Sho
Fujikawa, Shinya
Endo, Kaori
Koike, Shinsuke
Usami, Satoshi
Itokawa, Masanari
Washizuka, Shinsuke
Hiraiwa-Hasegawa, Mariko
Meltzer, Herbert Y.
Kasai, Kiyoto
Nishida, Atsushi
Arai, Makoto
author_sort Suzuki, Kazuhiro
collection PubMed
description Muscular strength, assessed by handgrip, is a risk indicator for psychiatric disorders, including psychosis. However, the biological mechanisms underlying this association remain unclear. Since advanced glycation end products (AGEs) play a key role in skeletal muscle underdevelopment and psychosis, we examined the role of AGEs in the longitudinal association between muscular strength and psychotic symptoms among adolescents. We first evaluated the direction of the relationship between handgrip strength and urine levels of pentosidine, a representative AGEs in a population-based birth cohort of 1,542 adolescents at ages 12 and 14. Then, we examined the role of AGEs in the longitudinal association between handgrip strength and thought problems (TP), as a psychotic symptom indicator, in a subsample of 256 adolescents at ages 13 and 14. An autoregressive cross-lagged model revealed that handgrip strength at age 12 negatively predicted pentosidine levels at age 14 (β = −0.20, p < 0.001), whereas pentosidine levels at age 12 did not predict handgrip strength at age 14 (β = 0.04, p = 0.062). Moreover, pentosidine levels had a significant indirect effect on the relationship between handgrip strength and TP (standard indirect effect = −0.051, p = 0.012), which remained significant after adjusting for gender and preceded TP and pentosidine levels. Thus, adolescents with low muscular strength are at a high risk of developing psychotic symptoms, which could be mediated by AGEs. Future studies need to investigate whether interventions focused on muscular strength prevent the accumulation of AGEs and thereby prevent the development of psychosis.
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spelling pubmed-92610852022-07-13 Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents Suzuki, Kazuhiro Yamasaki, Syudo Miyashita, Mitsuhiro Ando, Shuntaro Toriumi, Kazuya Yoshikawa, Akane Nakanishi, Miharu Morimoto, Yuko Kanata, Sho Fujikawa, Shinya Endo, Kaori Koike, Shinsuke Usami, Satoshi Itokawa, Masanari Washizuka, Shinsuke Hiraiwa-Hasegawa, Mariko Meltzer, Herbert Y. Kasai, Kiyoto Nishida, Atsushi Arai, Makoto Schizophrenia (Heidelb) Article Muscular strength, assessed by handgrip, is a risk indicator for psychiatric disorders, including psychosis. However, the biological mechanisms underlying this association remain unclear. Since advanced glycation end products (AGEs) play a key role in skeletal muscle underdevelopment and psychosis, we examined the role of AGEs in the longitudinal association between muscular strength and psychotic symptoms among adolescents. We first evaluated the direction of the relationship between handgrip strength and urine levels of pentosidine, a representative AGEs in a population-based birth cohort of 1,542 adolescents at ages 12 and 14. Then, we examined the role of AGEs in the longitudinal association between handgrip strength and thought problems (TP), as a psychotic symptom indicator, in a subsample of 256 adolescents at ages 13 and 14. An autoregressive cross-lagged model revealed that handgrip strength at age 12 negatively predicted pentosidine levels at age 14 (β = −0.20, p < 0.001), whereas pentosidine levels at age 12 did not predict handgrip strength at age 14 (β = 0.04, p = 0.062). Moreover, pentosidine levels had a significant indirect effect on the relationship between handgrip strength and TP (standard indirect effect = −0.051, p = 0.012), which remained significant after adjusting for gender and preceded TP and pentosidine levels. Thus, adolescents with low muscular strength are at a high risk of developing psychotic symptoms, which could be mediated by AGEs. Future studies need to investigate whether interventions focused on muscular strength prevent the accumulation of AGEs and thereby prevent the development of psychosis. Nature Publishing Group UK 2022-04-27 /pmc/articles/PMC9261085/ /pubmed/35853893 http://dx.doi.org/10.1038/s41537-022-00249-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Suzuki, Kazuhiro
Yamasaki, Syudo
Miyashita, Mitsuhiro
Ando, Shuntaro
Toriumi, Kazuya
Yoshikawa, Akane
Nakanishi, Miharu
Morimoto, Yuko
Kanata, Sho
Fujikawa, Shinya
Endo, Kaori
Koike, Shinsuke
Usami, Satoshi
Itokawa, Masanari
Washizuka, Shinsuke
Hiraiwa-Hasegawa, Mariko
Meltzer, Herbert Y.
Kasai, Kiyoto
Nishida, Atsushi
Arai, Makoto
Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents
title Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents
title_full Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents
title_fullStr Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents
title_full_unstemmed Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents
title_short Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents
title_sort role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261085/
https://www.ncbi.nlm.nih.gov/pubmed/35853893
http://dx.doi.org/10.1038/s41537-022-00249-5
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