Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel

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The individual-level effectiveness of vaccines against COVID-19 is well-established. However, few studies have examined vaccine effectiveness against transmission. We used a chain binomial model to estimate the effectiveness of vaccination with BNT162b2 (Pfizer-BioNTech mRNA-based vaccine) against h...

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Autores principales: Prunas, Ottavia, Warren, Joshua L., Crawford, Forrest W., Gazit, Sivan, Patalon, Tal, Weinberger, Daniel M., Pitzer, Virginia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261115/
https://www.ncbi.nlm.nih.gov/pubmed/35084937
http://dx.doi.org/10.1126/science.abl4292
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author Prunas, Ottavia
Warren, Joshua L.
Crawford, Forrest W.
Gazit, Sivan
Patalon, Tal
Weinberger, Daniel M.
Pitzer, Virginia E.
author_facet Prunas, Ottavia
Warren, Joshua L.
Crawford, Forrest W.
Gazit, Sivan
Patalon, Tal
Weinberger, Daniel M.
Pitzer, Virginia E.
author_sort Prunas, Ottavia
collection PubMed
description The individual-level effectiveness of vaccines against COVID-19 is well-established. However, few studies have examined vaccine effectiveness against transmission. We used a chain binomial model to estimate the effectiveness of vaccination with BNT162b2 (Pfizer-BioNTech mRNA-based vaccine) against household transmission of SARS-CoV-2 in Israel before and after the Delta variant emerged. Vaccination reduced susceptibility to infection by 89.4% (95% confidence interval (CI): 88.7%, 90.0%), while the vaccine effectiveness against infectiousness given infection was 23.0% (95% CI: −11.3%, 46.7%) during days 10–90 after the second dose prior to June 1, 2021. Total vaccine effectiveness was 91.8%, 95% CI: 88.1%, 94.3%). However, vaccine effectiveness is reduced over time due to the combined effect of waning of immunity and the emergence of the Delta variant.
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spelling pubmed-92611152022-09-11 Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel Prunas, Ottavia Warren, Joshua L. Crawford, Forrest W. Gazit, Sivan Patalon, Tal Weinberger, Daniel M. Pitzer, Virginia E. Science Article The individual-level effectiveness of vaccines against COVID-19 is well-established. However, few studies have examined vaccine effectiveness against transmission. We used a chain binomial model to estimate the effectiveness of vaccination with BNT162b2 (Pfizer-BioNTech mRNA-based vaccine) against household transmission of SARS-CoV-2 in Israel before and after the Delta variant emerged. Vaccination reduced susceptibility to infection by 89.4% (95% confidence interval (CI): 88.7%, 90.0%), while the vaccine effectiveness against infectiousness given infection was 23.0% (95% CI: −11.3%, 46.7%) during days 10–90 after the second dose prior to June 1, 2021. Total vaccine effectiveness was 91.8%, 95% CI: 88.1%, 94.3%). However, vaccine effectiveness is reduced over time due to the combined effect of waning of immunity and the emergence of the Delta variant. 2022-03-11 2022-01-27 /pmc/articles/PMC9261115/ /pubmed/35084937 http://dx.doi.org/10.1126/science.abl4292 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. This license does not apply to figures/photos/artwork or other content included in the article that is credited to a third party; obtain authorization from the rights holder before using such material.
spellingShingle Article
Prunas, Ottavia
Warren, Joshua L.
Crawford, Forrest W.
Gazit, Sivan
Patalon, Tal
Weinberger, Daniel M.
Pitzer, Virginia E.
Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel
title Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel
title_full Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel
title_fullStr Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel
title_full_unstemmed Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel
title_short Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel
title_sort vaccination with bnt162b2 reduces transmission of sars-cov-2 to household contacts in israel
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261115/
https://www.ncbi.nlm.nih.gov/pubmed/35084937
http://dx.doi.org/10.1126/science.abl4292
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