Growth Differentiation Factor-15 in Immunity and Aging

Aging increases susceptibility to and severity of a variety of chronic and infectious diseases. Underlying this is dysfunction of the immune system, including chronic increases in low-grade inflammation (inflammaging) and age-related immunosuppression (immunosenescence). Growth differentiation facto...

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Autor principal: Pence, Brandt D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261309/
https://www.ncbi.nlm.nih.gov/pubmed/35821815
http://dx.doi.org/10.3389/fragi.2022.837575
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author Pence, Brandt D.
author_facet Pence, Brandt D.
author_sort Pence, Brandt D.
collection PubMed
description Aging increases susceptibility to and severity of a variety of chronic and infectious diseases. Underlying this is dysfunction of the immune system, including chronic increases in low-grade inflammation (inflammaging) and age-related immunosuppression (immunosenescence). Growth differentiation factor-15 (GDF-15) is a stress-, infection-, and inflammation-induced cytokine which is increased in aging and suppresses immune responses. This mini review briefly covers existing knowledge on the immunoregulatory and anti-inflammatory roles of GDF-15, as well as its potential importance in aging and immune function.
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spelling pubmed-92613092022-07-11 Growth Differentiation Factor-15 in Immunity and Aging Pence, Brandt D. Front Aging Aging Aging increases susceptibility to and severity of a variety of chronic and infectious diseases. Underlying this is dysfunction of the immune system, including chronic increases in low-grade inflammation (inflammaging) and age-related immunosuppression (immunosenescence). Growth differentiation factor-15 (GDF-15) is a stress-, infection-, and inflammation-induced cytokine which is increased in aging and suppresses immune responses. This mini review briefly covers existing knowledge on the immunoregulatory and anti-inflammatory roles of GDF-15, as well as its potential importance in aging and immune function. Frontiers Media S.A. 2022-02-09 /pmc/articles/PMC9261309/ /pubmed/35821815 http://dx.doi.org/10.3389/fragi.2022.837575 Text en Copyright © 2022 Pence. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Pence, Brandt D.
Growth Differentiation Factor-15 in Immunity and Aging
title Growth Differentiation Factor-15 in Immunity and Aging
title_full Growth Differentiation Factor-15 in Immunity and Aging
title_fullStr Growth Differentiation Factor-15 in Immunity and Aging
title_full_unstemmed Growth Differentiation Factor-15 in Immunity and Aging
title_short Growth Differentiation Factor-15 in Immunity and Aging
title_sort growth differentiation factor-15 in immunity and aging
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261309/
https://www.ncbi.nlm.nih.gov/pubmed/35821815
http://dx.doi.org/10.3389/fragi.2022.837575
work_keys_str_mv AT pencebrandtd growthdifferentiationfactor15inimmunityandaging

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