Cellular Senescence and Ageing: Mechanisms and Interventions

The influence of the activation of a cellular phenotype termed senescence and it’s importance in ageing and age-related diseases is becoming more and more evident. In fact, there is a huge effort to tackle these diseases via therapeutic drugs targeting senescent cells named senolytics. However, a cl...

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Detalles Bibliográficos
Autores principales: Mylonas, Andreas, O’Loghlen, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261318/
https://www.ncbi.nlm.nih.gov/pubmed/35821824
http://dx.doi.org/10.3389/fragi.2022.866718
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author Mylonas, Andreas
O’Loghlen, Ana
author_facet Mylonas, Andreas
O’Loghlen, Ana
author_sort Mylonas, Andreas
collection PubMed
description The influence of the activation of a cellular phenotype termed senescence and it’s importance in ageing and age-related diseases is becoming more and more evident. In fact, there is a huge effort to tackle these diseases via therapeutic drugs targeting senescent cells named senolytics. However, a clearer understanding of how senescence is activated and the influence it has on specific cellular types and tissues is needed. Here, we describe general triggers and characteristics of senescence. In addition, we describe the influence of senescent cells in ageing and different age-related diseases.
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spelling pubmed-92613182022-07-11 Cellular Senescence and Ageing: Mechanisms and Interventions Mylonas, Andreas O’Loghlen, Ana Front Aging Aging The influence of the activation of a cellular phenotype termed senescence and it’s importance in ageing and age-related diseases is becoming more and more evident. In fact, there is a huge effort to tackle these diseases via therapeutic drugs targeting senescent cells named senolytics. However, a clearer understanding of how senescence is activated and the influence it has on specific cellular types and tissues is needed. Here, we describe general triggers and characteristics of senescence. In addition, we describe the influence of senescent cells in ageing and different age-related diseases. Frontiers Media S.A. 2022-03-29 /pmc/articles/PMC9261318/ /pubmed/35821824 http://dx.doi.org/10.3389/fragi.2022.866718 Text en Copyright © 2022 Mylonas and O’Loghlen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Mylonas, Andreas
O’Loghlen, Ana
Cellular Senescence and Ageing: Mechanisms and Interventions
title Cellular Senescence and Ageing: Mechanisms and Interventions
title_full Cellular Senescence and Ageing: Mechanisms and Interventions
title_fullStr Cellular Senescence and Ageing: Mechanisms and Interventions
title_full_unstemmed Cellular Senescence and Ageing: Mechanisms and Interventions
title_short Cellular Senescence and Ageing: Mechanisms and Interventions
title_sort cellular senescence and ageing: mechanisms and interventions
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261318/
https://www.ncbi.nlm.nih.gov/pubmed/35821824
http://dx.doi.org/10.3389/fragi.2022.866718
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