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New Roles for MicroRNAs in Old Worms
The use of Caenorhabditis elegans as a model organism in aging research has been integral to our understanding of genes and pathways involved in this process. Several well-conserved signaling pathways that respond to insulin signaling, diet, and assaults to proteostasis have defined roles in control...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261348/ https://www.ncbi.nlm.nih.gov/pubmed/35821862 http://dx.doi.org/10.3389/fragi.2022.871226 |
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author | Elder, Corrina R. Pasquinelli, Amy E. |
author_facet | Elder, Corrina R. Pasquinelli, Amy E. |
author_sort | Elder, Corrina R. |
collection | PubMed |
description | The use of Caenorhabditis elegans as a model organism in aging research has been integral to our understanding of genes and pathways involved in this process. Several well-conserved signaling pathways that respond to insulin signaling, diet, and assaults to proteostasis have defined roles in controlling lifespan. New evidence shows that microRNAs (miRNAs) play prominent roles in regulating these pathways. In some cases, key aging-related genes have been established as direct targets of specific miRNAs. However, the precise functions of other miRNAs and their protein cofactors in promoting or antagonizing longevity still need to be determined. Here, we highlight recently uncovered roles of miRNAs in common aging pathways, as well as new techniques for the ongoing discovery of miRNA functions in aging C. elegans. |
format | Online Article Text |
id | pubmed-9261348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92613482022-07-11 New Roles for MicroRNAs in Old Worms Elder, Corrina R. Pasquinelli, Amy E. Front Aging Aging The use of Caenorhabditis elegans as a model organism in aging research has been integral to our understanding of genes and pathways involved in this process. Several well-conserved signaling pathways that respond to insulin signaling, diet, and assaults to proteostasis have defined roles in controlling lifespan. New evidence shows that microRNAs (miRNAs) play prominent roles in regulating these pathways. In some cases, key aging-related genes have been established as direct targets of specific miRNAs. However, the precise functions of other miRNAs and their protein cofactors in promoting or antagonizing longevity still need to be determined. Here, we highlight recently uncovered roles of miRNAs in common aging pathways, as well as new techniques for the ongoing discovery of miRNA functions in aging C. elegans. Frontiers Media S.A. 2022-04-12 /pmc/articles/PMC9261348/ /pubmed/35821862 http://dx.doi.org/10.3389/fragi.2022.871226 Text en Copyright © 2022 Elder and Pasquinelli. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Elder, Corrina R. Pasquinelli, Amy E. New Roles for MicroRNAs in Old Worms |
title | New Roles for MicroRNAs in Old Worms |
title_full | New Roles for MicroRNAs in Old Worms |
title_fullStr | New Roles for MicroRNAs in Old Worms |
title_full_unstemmed | New Roles for MicroRNAs in Old Worms |
title_short | New Roles for MicroRNAs in Old Worms |
title_sort | new roles for micrornas in old worms |
topic | Aging |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261348/ https://www.ncbi.nlm.nih.gov/pubmed/35821862 http://dx.doi.org/10.3389/fragi.2022.871226 |
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