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Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models
Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies. During the aging process, senescent cell accumulation...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261353/ https://www.ncbi.nlm.nih.gov/pubmed/35821852 http://dx.doi.org/10.3389/fragi.2022.828058 |
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author | Inci, Nurcan Kamali, Dilanur Akyildiz, Erdogan Oguzhan Tahir Turanli, Eda Bozaykut, Perinur |
author_facet | Inci, Nurcan Kamali, Dilanur Akyildiz, Erdogan Oguzhan Tahir Turanli, Eda Bozaykut, Perinur |
author_sort | Inci, Nurcan |
collection | PubMed |
description | Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies. During the aging process, senescent cell accumulation results in senescence-associated secretory phenotype (SASP) which plays an essential role in tissue dysfunction. Although discovered very recently, senotherapeutic drugs have been already involved in clinical studies. This review gives a summary of the molecular mechanisms of CS and its role particularly in the development of cardiovascular diseases (CVD) as the leading cause of death. In addition, it addresses alternative research tools including the nonhuman and human models as well as computational techniques for the discovery of novel therapies. Finally, senotherapeutic approaches that are mainly classified as senolytics and senomorphics are discussed. |
format | Online Article Text |
id | pubmed-9261353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92613532022-07-11 Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models Inci, Nurcan Kamali, Dilanur Akyildiz, Erdogan Oguzhan Tahir Turanli, Eda Bozaykut, Perinur Front Aging Aging Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies. During the aging process, senescent cell accumulation results in senescence-associated secretory phenotype (SASP) which plays an essential role in tissue dysfunction. Although discovered very recently, senotherapeutic drugs have been already involved in clinical studies. This review gives a summary of the molecular mechanisms of CS and its role particularly in the development of cardiovascular diseases (CVD) as the leading cause of death. In addition, it addresses alternative research tools including the nonhuman and human models as well as computational techniques for the discovery of novel therapies. Finally, senotherapeutic approaches that are mainly classified as senolytics and senomorphics are discussed. Frontiers Media S.A. 2022-06-01 /pmc/articles/PMC9261353/ /pubmed/35821852 http://dx.doi.org/10.3389/fragi.2022.828058 Text en Copyright © 2022 Inci, Kamali, Akyildiz, Tahir Turanli and Bozaykut. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Inci, Nurcan Kamali, Dilanur Akyildiz, Erdogan Oguzhan Tahir Turanli, Eda Bozaykut, Perinur Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models |
title | Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models |
title_full | Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models |
title_fullStr | Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models |
title_full_unstemmed | Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models |
title_short | Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models |
title_sort | translation of cellular senescence to novel therapeutics: insights from alternative tools and models |
topic | Aging |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261353/ https://www.ncbi.nlm.nih.gov/pubmed/35821852 http://dx.doi.org/10.3389/fragi.2022.828058 |
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