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Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models

Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies. During the aging process, senescent cell accumulation...

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Autores principales: Inci, Nurcan, Kamali, Dilanur, Akyildiz, Erdogan Oguzhan, Tahir Turanli, Eda, Bozaykut, Perinur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261353/
https://www.ncbi.nlm.nih.gov/pubmed/35821852
http://dx.doi.org/10.3389/fragi.2022.828058
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author Inci, Nurcan
Kamali, Dilanur
Akyildiz, Erdogan Oguzhan
Tahir Turanli, Eda
Bozaykut, Perinur
author_facet Inci, Nurcan
Kamali, Dilanur
Akyildiz, Erdogan Oguzhan
Tahir Turanli, Eda
Bozaykut, Perinur
author_sort Inci, Nurcan
collection PubMed
description Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies. During the aging process, senescent cell accumulation results in senescence-associated secretory phenotype (SASP) which plays an essential role in tissue dysfunction. Although discovered very recently, senotherapeutic drugs have been already involved in clinical studies. This review gives a summary of the molecular mechanisms of CS and its role particularly in the development of cardiovascular diseases (CVD) as the leading cause of death. In addition, it addresses alternative research tools including the nonhuman and human models as well as computational techniques for the discovery of novel therapies. Finally, senotherapeutic approaches that are mainly classified as senolytics and senomorphics are discussed.
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spelling pubmed-92613532022-07-11 Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models Inci, Nurcan Kamali, Dilanur Akyildiz, Erdogan Oguzhan Tahir Turanli, Eda Bozaykut, Perinur Front Aging Aging Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies. During the aging process, senescent cell accumulation results in senescence-associated secretory phenotype (SASP) which plays an essential role in tissue dysfunction. Although discovered very recently, senotherapeutic drugs have been already involved in clinical studies. This review gives a summary of the molecular mechanisms of CS and its role particularly in the development of cardiovascular diseases (CVD) as the leading cause of death. In addition, it addresses alternative research tools including the nonhuman and human models as well as computational techniques for the discovery of novel therapies. Finally, senotherapeutic approaches that are mainly classified as senolytics and senomorphics are discussed. Frontiers Media S.A. 2022-06-01 /pmc/articles/PMC9261353/ /pubmed/35821852 http://dx.doi.org/10.3389/fragi.2022.828058 Text en Copyright © 2022 Inci, Kamali, Akyildiz, Tahir Turanli and Bozaykut. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Inci, Nurcan
Kamali, Dilanur
Akyildiz, Erdogan Oguzhan
Tahir Turanli, Eda
Bozaykut, Perinur
Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models
title Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models
title_full Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models
title_fullStr Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models
title_full_unstemmed Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models
title_short Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models
title_sort translation of cellular senescence to novel therapeutics: insights from alternative tools and models
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261353/
https://www.ncbi.nlm.nih.gov/pubmed/35821852
http://dx.doi.org/10.3389/fragi.2022.828058
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