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Differential Effects of 2-Deoxyglucose and Glucose Deprivation on 4-Hydroxynonenal Dependent Mitochondrial Dysfunction in Primary Neurons

Mitochondrial dysfunction and metabolic decline are prevalent features of aging and age-related disorders, including neurodegeneration. Neurodegenerative diseases are associated with a progressive loss of metabolic homeostasis. This pathogenic decline in metabolism is the result of several factors,...

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Detalles Bibliográficos
Autores principales: Dodson, Matthew, Benavides, Gloria A., Darley-Usmar, Victor, Zhang, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261388/
https://www.ncbi.nlm.nih.gov/pubmed/35821809
http://dx.doi.org/10.3389/fragi.2022.812810