Cargando…

Metformin Enhances B Cell Function and Antibody Responses of Elderly Individuals With Type-2 Diabetes Mellitus

Our previous work has shown that young and elderly patients with Type-2 Diabetes Mellitus (T2DM) treated with Metformin have optimal B cell function and serum antibodies specific for the seasonal influenza vaccine. In this paper, we have evaluated B cell function and the metabolic requirements of B...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frasca, Daniela, Diaz, Alain, Romero, Maria, Blomberg, Bonnie B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Aging
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261392/ https://www.ncbi.nlm.nih.gov/pubmed/35822013 http://dx.doi.org/10.3389/fragi.2021.715981

Ejemplares similares

Obesity Accelerates Age-Associated Defects in Human B Cells Through a Metabolic Reprogramming Induced by the Fatty Acid Palmitate
por: Frasca, Daniela, et al.
Publicado: (2022)

Phenotypic and Functional Characterization of Double Negative B Cells in the Blood of Individuals With Obesity
por: Frasca, Daniela, et al.
Publicado: (2021)

Hyper‐metabolic B cells in the spleens of old mice make antibodies with autoimmune specificities
por: Frasca, Daniela, et al.
Publicado: (2021)

Metformin Attenuates Inflammatory Responses and Enhances Antibody Production in an Acute Pneumonia Model of Streptococcus pneumoniae
por: Lee, Grace C., et al.
Publicado: (2022)

B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity
por: Frasca, Daniela, et al.
Publicado: (2021)

Obesity accelerates age defects in B cells, and weight loss improves B cell function
por: Frasca, Daniela, et al.
Publicado: (2023)

Secretion of autoimmune antibodies in the human subcutaneous adipose tissue
por: Frasca, Daniela, et al.
Publicado: (2018)

Comments on the evaluation of lymphocyte levels in a random sample of 218 elderly individuals from São Paulo city
por: Blomberg, Bonnie B., et al.
Publicado: (2011)

Mini-review: Angiotensin- converting enzyme 1 (ACE1) and the impact for diseases such as Alzheimer’s disease, sarcopenia, cancer, and COVID-19
por: Bueno, Valquiria, et al.
Publicado: (2023)

Metabolic requirements of human pro-inflammatory B cells in aging and obesity
por: Frasca, Daniela, et al.
Publicado: (2019)

Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination
por: Frasca, Daniela, et al.
Publicado: (2020)

Editorial: “Obesity, Metabolism and the immune system”
por: Frasca, Daniela, et al.
Publicado: (2022)

Phenotypic and functional features of B cells from two different human subcutaneous adipose depots
por: Frasca, Daniela, et al.
Publicado: (2023)

Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients
por: Frasca, Daniela, et al.
Publicado: (2021)

The majority of SARS-CoV-2-specific antibodies in COVID-19 patients with obesity are autoimmune and not neutralizing
por: Frasca, Daniela, et al.
Publicado: (2021)

Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging
por: Frasca, Daniela, et al.
Publicado: (2017)

Obesity Accelerates Age Defects in Mouse and Human B Cells
por: Frasca, Daniela, et al.
Publicado: (2020)

AID Activity in B Cells Strongly Correlates with Polyclonal Antibody Affinity Maturation in-vivo Following Pandemic 2009-H1N1 Vaccination in Humans
por: Khurana, Surender, et al.
Publicado: (2012)

Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells
por: Abdelgawad, Ibrahim Y., et al.
Publicado: (2023)

Identification and Characterization of Adipose Tissue-Derived Human Antibodies With “Anti-self” Specificity
por: Frasca, Daniela, et al.
Publicado: (2020)

Old drug, new tricks: the utility of metformin in infection and vaccination responses to influenza and SARS-CoV-2 in older adults
por: Martin, Dominique E., et al.
Publicado: (2023)

Abnormal functional connectivity of the frontostriatal circuits in type 2 diabetes mellitus
por: Fu, Yingxia, et al.
Publicado: (2023)

Impaired B Cell Function in Mice Lacking Perforin-2
por: Frasca, Daniela, et al.
Publicado: (2020)

Evaluation of serum vitamin b12 in elderly individuals with type 2 diabetes mellitus, with and without dementia, in relation to the use of metformin
por: Navarro, Danilo Hojo, et al.
Publicado: (2015)

Low But Recoverable Markers of Humoral Immune Response to BNT162b2 in Elderly LTCF Residents Five to Seven Months After Two-Dose Vaccination
por: Delbrück, Marla, et al.
Publicado: (2022)

Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus
por: Huang, Juan, et al.
Publicado: (2023)

Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly
por: Shive, Carey, et al.
Publicado: (2022)

NK- and T-cell granzyme B and K expression correlates with age, CMV infection and influenza vaccine-induced antibody titres in older adults
por: Verschoor, Chris P., et al.
Publicado: (2023)

Effects of age on H1N1-specific serum IgG1 and IgG3 levels evaluated during the 2011–2012 influenza vaccine season
por: Frasca, Daniela, et al.
Publicado: (2013)

Aging and CMV Infection Affect Pre-existing SARS-CoV-2-Reactive CD8(+) T Cells in Unexposed Individuals
por: Jo, Norihide, et al.
Publicado: (2021)

The Correlation Between Falls and Cognitive Frailty in Elderly Individuals With Hypertension in a Chinese Community
por: Wang, Can, et al.
Publicado: (2022)

Exploring the common pathogenesis of Alzheimer’s disease and type 2 diabetes mellitus via microarray data analysis
por: Ye, Xian-wen, et al.
Publicado: (2023)

Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification
por: Lázničková, Petra, et al.
Publicado: (2021)

Association of dietary patterns and sarcopenia in the elderly population: a cross-sectional study
por: Wang, Boshi, et al.
Publicado: (2023)

Age-associated alterations in γδ T-cells are present predominantly in individuals infected with Cytomegalovirus
por: Wistuba-Hamprecht, Kilian, et al.
Publicado: (2013)

Risk factors of osteoporosis in elderly inpatients: A cross-sectional single-centre study
por: Li, Han, et al.
Publicado: (2023)

Topological Alterations of the Brain Functional Network in Type 2 Diabetes Mellitus Patients With and Without Mild Cognitive Impairment
por: Zhou, Baiwan, et al.
Publicado: (2022)

Metabolic phenotype of B cells from young and elderly HIV individuals
por: Frasca, Daniela, et al.
Publicado: (2021)

Secondary metformin monotherapy failure in individuals with type 2 diabetes mellitus
por: Weiss, Tracey, et al.
Publicado: (2021)

25-OH vitamin D threshold for optimal bone mineral density in elderly patients with chronic kidney disease
por: Roy, Debajyoti, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4bd2qiokf9402ob0etmj00vjh8