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Inhibiting BDNF Signaling Upregulates Hippocampal H3K9me3 in a Manner Dependent On In Vitro Aging and Oxidative Stress

Histone modifications are key contributors to the cognitive decline that occurs in aging and Alzheimer’s disease. Our lab has previously shown that elevated H3K9me3 in aged mice is correlated with synaptic loss, cognitive impairment and a reduction in brain derived neurotrophic factor (BDNF). Howeve...

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Detalles Bibliográficos
Autores principales:	Ionescu-Tucker, Andra, Tong, Liqi, Berchtold, Nicole C., Cotman, Carl W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Aging
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261402/ https://www.ncbi.nlm.nih.gov/pubmed/35821854 http://dx.doi.org/10.3389/fragi.2022.796087

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