The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections

Respiratory infections are one of the top causes of death in the elderly population, displaying susceptibility factors with increasing age that are potentially amenable to interventions. We posit that with increasing age there are predictable tissue-specific changes that prevent the immune system fr...

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Autores principales: Torrelles, Jordi B., Restrepo, Blanca I., Bai, Yidong, Ross, Corinna, Schlesinger, Larry S., Turner, Joanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261427/
https://www.ncbi.nlm.nih.gov/pubmed/35821836
http://dx.doi.org/10.3389/fragi.2022.818700
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author Torrelles, Jordi B.
Restrepo, Blanca I.
Bai, Yidong
Ross, Corinna
Schlesinger, Larry S.
Turner, Joanne
author_facet Torrelles, Jordi B.
Restrepo, Blanca I.
Bai, Yidong
Ross, Corinna
Schlesinger, Larry S.
Turner, Joanne
author_sort Torrelles, Jordi B.
collection PubMed
description Respiratory infections are one of the top causes of death in the elderly population, displaying susceptibility factors with increasing age that are potentially amenable to interventions. We posit that with increasing age there are predictable tissue-specific changes that prevent the immune system from working effectively in the lung. This mini-review highlights recent evidence for altered local tissue environment factors as we age focusing on increased tissue oxidative stress with associated immune cell changes, likely driven by the byproducts of age-associated inflammatory disease. Potential intervention points are presented.
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spelling pubmed-92614272022-07-11 The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections Torrelles, Jordi B. Restrepo, Blanca I. Bai, Yidong Ross, Corinna Schlesinger, Larry S. Turner, Joanne Front Aging Aging Respiratory infections are one of the top causes of death in the elderly population, displaying susceptibility factors with increasing age that are potentially amenable to interventions. We posit that with increasing age there are predictable tissue-specific changes that prevent the immune system from working effectively in the lung. This mini-review highlights recent evidence for altered local tissue environment factors as we age focusing on increased tissue oxidative stress with associated immune cell changes, likely driven by the byproducts of age-associated inflammatory disease. Potential intervention points are presented. Frontiers Media S.A. 2022-01-19 /pmc/articles/PMC9261427/ /pubmed/35821836 http://dx.doi.org/10.3389/fragi.2022.818700 Text en Copyright © 2022 Torrelles, Restrepo, Bai, Ross, Schlesinger and Turner. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Torrelles, Jordi B.
Restrepo, Blanca I.
Bai, Yidong
Ross, Corinna
Schlesinger, Larry S.
Turner, Joanne
The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections
title The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections
title_full The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections
title_fullStr The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections
title_full_unstemmed The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections
title_short The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections
title_sort impact of aging on the lung alveolar environment, predetermining susceptibility to respiratory infections
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261427/
https://www.ncbi.nlm.nih.gov/pubmed/35821836
http://dx.doi.org/10.3389/fragi.2022.818700
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