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Low But Recoverable Markers of Humoral Immune Response to BNT162b2 in Elderly LTCF Residents Five to Seven Months After Two-Dose Vaccination

The immune response is known to wane after vaccination with BNT162b2, but the role of age, morbidity and body composition is not well understood. We conducted a cross-sectional study in long-term care facilities (LTCFs) for the elderly. All study participants had completed two-dose vaccination with...

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Autores principales: Delbrück, Marla, Hoehl, Sebastian, Toptan, Tuna, Schenk, Barbara, Grikscheit, Katharina, Metzler, Melinda, Herrmann, Eva, Ciesek, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261435/
https://www.ncbi.nlm.nih.gov/pubmed/35821813
http://dx.doi.org/10.3389/fragi.2022.883724
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author Delbrück, Marla
Hoehl, Sebastian
Toptan, Tuna
Schenk, Barbara
Grikscheit, Katharina
Metzler, Melinda
Herrmann, Eva
Ciesek, Sandra
author_facet Delbrück, Marla
Hoehl, Sebastian
Toptan, Tuna
Schenk, Barbara
Grikscheit, Katharina
Metzler, Melinda
Herrmann, Eva
Ciesek, Sandra
author_sort Delbrück, Marla
collection PubMed
description The immune response is known to wane after vaccination with BNT162b2, but the role of age, morbidity and body composition is not well understood. We conducted a cross-sectional study in long-term care facilities (LTCFs) for the elderly. All study participants had completed two-dose vaccination with BNT162b2 five to 7 months before sample collection. In 298 residents (median age 86 years, range 75–101), anti-SARS-CoV-2 rector binding IgG antibody (anti-RBD-IgG) concentrations were low and inversely correlated with age (mean 51.60 BAU/ml). We compared the results to Health Care Workers (HCW) aged 18–70 years (n = 114, median age: 53 years), who had a higher mean anti-RBD-IgG concentration of 156.99 BAU/ml. Neutralization against the Delta variant was low in both groups (9.5% in LTCF residents and 31.6% in HCWs). The Charlson Comorbidity Index was inversely correlated with anti-RBD-IgG, but not the body mass index (BMI). A control group of 14 LTCF residents with known breakthrough infection had significant higher antibody concentrations (mean 3,199.65 BAU/ml), and 85.7% had detectable neutralization against the Delta variant. Our results demonstrate low but recoverable markers of immunity in LTCF residents five to 7 months after vaccination.
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spelling pubmed-92614352022-07-11 Low But Recoverable Markers of Humoral Immune Response to BNT162b2 in Elderly LTCF Residents Five to Seven Months After Two-Dose Vaccination Delbrück, Marla Hoehl, Sebastian Toptan, Tuna Schenk, Barbara Grikscheit, Katharina Metzler, Melinda Herrmann, Eva Ciesek, Sandra Front Aging Aging The immune response is known to wane after vaccination with BNT162b2, but the role of age, morbidity and body composition is not well understood. We conducted a cross-sectional study in long-term care facilities (LTCFs) for the elderly. All study participants had completed two-dose vaccination with BNT162b2 five to 7 months before sample collection. In 298 residents (median age 86 years, range 75–101), anti-SARS-CoV-2 rector binding IgG antibody (anti-RBD-IgG) concentrations were low and inversely correlated with age (mean 51.60 BAU/ml). We compared the results to Health Care Workers (HCW) aged 18–70 years (n = 114, median age: 53 years), who had a higher mean anti-RBD-IgG concentration of 156.99 BAU/ml. Neutralization against the Delta variant was low in both groups (9.5% in LTCF residents and 31.6% in HCWs). The Charlson Comorbidity Index was inversely correlated with anti-RBD-IgG, but not the body mass index (BMI). A control group of 14 LTCF residents with known breakthrough infection had significant higher antibody concentrations (mean 3,199.65 BAU/ml), and 85.7% had detectable neutralization against the Delta variant. Our results demonstrate low but recoverable markers of immunity in LTCF residents five to 7 months after vaccination. Frontiers Media S.A. 2022-04-25 /pmc/articles/PMC9261435/ /pubmed/35821813 http://dx.doi.org/10.3389/fragi.2022.883724 Text en Copyright © 2022 Delbrück, Hoehl, Toptan, Schenk, Grikscheit, Metzler, Herrmann and Ciesek. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Delbrück, Marla
Hoehl, Sebastian
Toptan, Tuna
Schenk, Barbara
Grikscheit, Katharina
Metzler, Melinda
Herrmann, Eva
Ciesek, Sandra
Low But Recoverable Markers of Humoral Immune Response to BNT162b2 in Elderly LTCF Residents Five to Seven Months After Two-Dose Vaccination
title Low But Recoverable Markers of Humoral Immune Response to BNT162b2 in Elderly LTCF Residents Five to Seven Months After Two-Dose Vaccination
title_full Low But Recoverable Markers of Humoral Immune Response to BNT162b2 in Elderly LTCF Residents Five to Seven Months After Two-Dose Vaccination
title_fullStr Low But Recoverable Markers of Humoral Immune Response to BNT162b2 in Elderly LTCF Residents Five to Seven Months After Two-Dose Vaccination
title_full_unstemmed Low But Recoverable Markers of Humoral Immune Response to BNT162b2 in Elderly LTCF Residents Five to Seven Months After Two-Dose Vaccination
title_short Low But Recoverable Markers of Humoral Immune Response to BNT162b2 in Elderly LTCF Residents Five to Seven Months After Two-Dose Vaccination
title_sort low but recoverable markers of humoral immune response to bnt162b2 in elderly ltcf residents five to seven months after two-dose vaccination
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261435/
https://www.ncbi.nlm.nih.gov/pubmed/35821813
http://dx.doi.org/10.3389/fragi.2022.883724
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