Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases

In recent years an expanding collection of heart-secreted signaling proteins have been discovered that play cellular communication roles in diverse pathophysiological processes. This minireview briefly discusses current evidence for the roles of cardiokines in systemic regulation of aging and age-as...

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Detalles Bibliográficos
Autores principales: Srivastava, Himangi, Pozzoli, Marina, Lau, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261440/
https://www.ncbi.nlm.nih.gov/pubmed/35821831
http://dx.doi.org/10.3389/fragi.2022.884321
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author Srivastava, Himangi
Pozzoli, Marina
Lau, Edward
author_facet Srivastava, Himangi
Pozzoli, Marina
Lau, Edward
author_sort Srivastava, Himangi
collection PubMed
description In recent years an expanding collection of heart-secreted signaling proteins have been discovered that play cellular communication roles in diverse pathophysiological processes. This minireview briefly discusses current evidence for the roles of cardiokines in systemic regulation of aging and age-associated diseases. An analysis of human transcriptome and secretome data suggests the possibility that many other cardiokines remain to be discovered that may function in long-range physiological regulations. We discuss the ongoing challenges and emerging technologies for elucidating the identity and function of cardiokines in endocrine regulations.
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spelling pubmed-92614402022-07-11 Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases Srivastava, Himangi Pozzoli, Marina Lau, Edward Front Aging Aging In recent years an expanding collection of heart-secreted signaling proteins have been discovered that play cellular communication roles in diverse pathophysiological processes. This minireview briefly discusses current evidence for the roles of cardiokines in systemic regulation of aging and age-associated diseases. An analysis of human transcriptome and secretome data suggests the possibility that many other cardiokines remain to be discovered that may function in long-range physiological regulations. We discuss the ongoing challenges and emerging technologies for elucidating the identity and function of cardiokines in endocrine regulations. Frontiers Media S.A. 2022-04-28 /pmc/articles/PMC9261440/ /pubmed/35821831 http://dx.doi.org/10.3389/fragi.2022.884321 Text en Copyright © 2022 Srivastava, Pozzoli and Lau. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Srivastava, Himangi
Pozzoli, Marina
Lau, Edward
Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases
title Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases
title_full Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases
title_fullStr Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases
title_full_unstemmed Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases
title_short Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases
title_sort defining the roles of cardiokines in human aging and age-associated diseases
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261440/
https://www.ncbi.nlm.nih.gov/pubmed/35821831
http://dx.doi.org/10.3389/fragi.2022.884321
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