Dynamic Progress in Technological Advances to Study Lipids in Aging: Challenges and Future Directions

Lipids participate in all cellular processes. Diverse methods have been developed to investigate lipid composition and distribution in biological samples to understand the effect of lipids across an organism’s lifespan. Here, we summarize the advanced techniques for studying lipids, including mass s...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Fangyuan, Tom, Emily, Skowronska-Krawczyk, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261449/
https://www.ncbi.nlm.nih.gov/pubmed/35821837
http://dx.doi.org/10.3389/fragi.2022.851073
_version_ 1784742280535474176
author Gao, Fangyuan
Tom, Emily
Skowronska-Krawczyk, Dorota
author_facet Gao, Fangyuan
Tom, Emily
Skowronska-Krawczyk, Dorota
author_sort Gao, Fangyuan
collection PubMed
description Lipids participate in all cellular processes. Diverse methods have been developed to investigate lipid composition and distribution in biological samples to understand the effect of lipids across an organism’s lifespan. Here, we summarize the advanced techniques for studying lipids, including mass spectrometry-based lipidomics, lipid imaging, chemical-based lipid analysis and lipid engineering and their advantages. We further discuss the limitation of the current methods to gain an in-depth knowledge of the role of lipids in aging, and the possibility of lipid-based therapy in aging-related diseases.
format Online
Article
Text
id pubmed-9261449
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92614492022-07-11 Dynamic Progress in Technological Advances to Study Lipids in Aging: Challenges and Future Directions Gao, Fangyuan Tom, Emily Skowronska-Krawczyk, Dorota Front Aging Aging Lipids participate in all cellular processes. Diverse methods have been developed to investigate lipid composition and distribution in biological samples to understand the effect of lipids across an organism’s lifespan. Here, we summarize the advanced techniques for studying lipids, including mass spectrometry-based lipidomics, lipid imaging, chemical-based lipid analysis and lipid engineering and their advantages. We further discuss the limitation of the current methods to gain an in-depth knowledge of the role of lipids in aging, and the possibility of lipid-based therapy in aging-related diseases. Frontiers Media S.A. 2022-03-10 /pmc/articles/PMC9261449/ /pubmed/35821837 http://dx.doi.org/10.3389/fragi.2022.851073 Text en Copyright © 2022 Gao, Tom and Skowronska-Krawczyk. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Gao, Fangyuan
Tom, Emily
Skowronska-Krawczyk, Dorota
Dynamic Progress in Technological Advances to Study Lipids in Aging: Challenges and Future Directions
title Dynamic Progress in Technological Advances to Study Lipids in Aging: Challenges and Future Directions
title_full Dynamic Progress in Technological Advances to Study Lipids in Aging: Challenges and Future Directions
title_fullStr Dynamic Progress in Technological Advances to Study Lipids in Aging: Challenges and Future Directions
title_full_unstemmed Dynamic Progress in Technological Advances to Study Lipids in Aging: Challenges and Future Directions
title_short Dynamic Progress in Technological Advances to Study Lipids in Aging: Challenges and Future Directions
title_sort dynamic progress in technological advances to study lipids in aging: challenges and future directions
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261449/
https://www.ncbi.nlm.nih.gov/pubmed/35821837
http://dx.doi.org/10.3389/fragi.2022.851073
work_keys_str_mv AT gaofangyuan dynamicprogressintechnologicaladvancestostudylipidsinagingchallengesandfuturedirections
AT tomemily dynamicprogressintechnologicaladvancestostudylipidsinagingchallengesandfuturedirections
AT skowronskakrawczykdorota dynamicprogressintechnologicaladvancestostudylipidsinagingchallengesandfuturedirections

Ejemplares similares