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Fecal Microbiota Transplantation Reshapes the Physiological Function of the Intestine in Antibiotic-Treated Specific Pathogen-Free Birds

The topic about the interactions between host and intestinal microbiota has already caught the attention of many scholars. However, there is still a lack of systematic reports on the relationship between the intestinal flora and intestinal physiology of birds. Thus, this study was designed to invest...

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Autores principales: Li, Peng, Gao, Mingkun, Song, Bochen, Liu, Yan, Yan, Shaojia, Lei, Jiaqi, Zhao, Yizhu, Li, Guang, Mahmood, Tahir, Lv, Zengpeng, Hu, Yongfei, Guo, Yuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261465/
https://www.ncbi.nlm.nih.gov/pubmed/35812374
http://dx.doi.org/10.3389/fimmu.2022.884615
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author Li, Peng
Gao, Mingkun
Song, Bochen
Liu, Yan
Yan, Shaojia
Lei, Jiaqi
Zhao, Yizhu
Li, Guang
Mahmood, Tahir
Lv, Zengpeng
Hu, Yongfei
Guo, Yuming
author_facet Li, Peng
Gao, Mingkun
Song, Bochen
Liu, Yan
Yan, Shaojia
Lei, Jiaqi
Zhao, Yizhu
Li, Guang
Mahmood, Tahir
Lv, Zengpeng
Hu, Yongfei
Guo, Yuming
author_sort Li, Peng
collection PubMed
description The topic about the interactions between host and intestinal microbiota has already caught the attention of many scholars. However, there is still a lack of systematic reports on the relationship between the intestinal flora and intestinal physiology of birds. Thus, this study was designed to investigate it. Antibiotic-treated specific pathogen-free (SPF) bird were used to construct an intestinal bacteria-free bird (IBF) model, and then, the differences in intestinal absorption, barrier, immune, antioxidant and metabolic functions between IBF and bacteria-bearing birds were studied. To gain further insight, the whole intestinal flora of bacteria-bearing birds was transplanted into the intestines of IBF birds to study the remodeling effect of fecal microbiota transplantation (FMT) on the intestinal physiology of IBF birds. The results showed that compared with bacteria-bearing birds, IBF birds had a lighter body weight and weaker intestinal absorption, antioxidant, barrier, immune and metabolic functions. Interestingly, FMT contributed to reshaping the abovementioned physiological functions of the intestines of IBF birds. In conclusion, the intestinal flora plays an important role in regulating the physiological functions of the intestine.
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spelling pubmed-92614652022-07-08 Fecal Microbiota Transplantation Reshapes the Physiological Function of the Intestine in Antibiotic-Treated Specific Pathogen-Free Birds Li, Peng Gao, Mingkun Song, Bochen Liu, Yan Yan, Shaojia Lei, Jiaqi Zhao, Yizhu Li, Guang Mahmood, Tahir Lv, Zengpeng Hu, Yongfei Guo, Yuming Front Immunol Immunology The topic about the interactions between host and intestinal microbiota has already caught the attention of many scholars. However, there is still a lack of systematic reports on the relationship between the intestinal flora and intestinal physiology of birds. Thus, this study was designed to investigate it. Antibiotic-treated specific pathogen-free (SPF) bird were used to construct an intestinal bacteria-free bird (IBF) model, and then, the differences in intestinal absorption, barrier, immune, antioxidant and metabolic functions between IBF and bacteria-bearing birds were studied. To gain further insight, the whole intestinal flora of bacteria-bearing birds was transplanted into the intestines of IBF birds to study the remodeling effect of fecal microbiota transplantation (FMT) on the intestinal physiology of IBF birds. The results showed that compared with bacteria-bearing birds, IBF birds had a lighter body weight and weaker intestinal absorption, antioxidant, barrier, immune and metabolic functions. Interestingly, FMT contributed to reshaping the abovementioned physiological functions of the intestines of IBF birds. In conclusion, the intestinal flora plays an important role in regulating the physiological functions of the intestine. Frontiers Media S.A. 2022-06-23 /pmc/articles/PMC9261465/ /pubmed/35812374 http://dx.doi.org/10.3389/fimmu.2022.884615 Text en Copyright © 2022 Li, Gao, Song, Liu, Yan, Lei, Zhao, Li, Mahmood, Lv, Hu and Guo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Li, Peng
Gao, Mingkun
Song, Bochen
Liu, Yan
Yan, Shaojia
Lei, Jiaqi
Zhao, Yizhu
Li, Guang
Mahmood, Tahir
Lv, Zengpeng
Hu, Yongfei
Guo, Yuming
Fecal Microbiota Transplantation Reshapes the Physiological Function of the Intestine in Antibiotic-Treated Specific Pathogen-Free Birds
title Fecal Microbiota Transplantation Reshapes the Physiological Function of the Intestine in Antibiotic-Treated Specific Pathogen-Free Birds
title_full Fecal Microbiota Transplantation Reshapes the Physiological Function of the Intestine in Antibiotic-Treated Specific Pathogen-Free Birds
title_fullStr Fecal Microbiota Transplantation Reshapes the Physiological Function of the Intestine in Antibiotic-Treated Specific Pathogen-Free Birds
title_full_unstemmed Fecal Microbiota Transplantation Reshapes the Physiological Function of the Intestine in Antibiotic-Treated Specific Pathogen-Free Birds
title_short Fecal Microbiota Transplantation Reshapes the Physiological Function of the Intestine in Antibiotic-Treated Specific Pathogen-Free Birds
title_sort fecal microbiota transplantation reshapes the physiological function of the intestine in antibiotic-treated specific pathogen-free birds
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261465/
https://www.ncbi.nlm.nih.gov/pubmed/35812374
http://dx.doi.org/10.3389/fimmu.2022.884615
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