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Carbon dots as artificial peroxidases for analytical applications

Nanozymes have become attractive in analytical and biomedical fields, mainly because of their low cost, long shelf life, and less environmental sensitivity. Particularly, nanozymes formed from nanomaterials having high surface area and rich active sites are interesting since their activities can be...

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Autores principales: Wei, Shih-Chun, Lin, Yang-Wei, Chang, Huan-Tsung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261811/
https://www.ncbi.nlm.nih.gov/pubmed/35696142
http://dx.doi.org/10.38212/2224-6614.1090
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author Wei, Shih-Chun
Lin, Yang-Wei
Chang, Huan-Tsung
author_facet Wei, Shih-Chun
Lin, Yang-Wei
Chang, Huan-Tsung
author_sort Wei, Shih-Chun
collection PubMed
description Nanozymes have become attractive in analytical and biomedical fields, mainly because of their low cost, long shelf life, and less environmental sensitivity. Particularly, nanozymes formed from nanomaterials having high surface area and rich active sites are interesting since their activities can be tuned through carefully controlling their size, morphology, and surface properties. This review article focuses on preparation of carbon dots (C dots) possessing peroxidase-like activity and their analytical applications. We highlight the important roles of the oxidation states and surface residues of C dots and their nanocomposites with metal, metal oxides, or metal sulfides playing on determining their specificity and sensitivity toward H(2)O(2). Examples of C dot nanozymes (CDzymes) for developing sensitive and selective absorption, fluorescence, and electrochemical sensing systems in the presence of substrates are presented to show their potential in analytical applications. For example, CDzymes couple with glucose oxidase and cholesterol oxidase are specific and sensitive for quantitation of glucose and cholesterol, separately, when using 3,3′,5,5′-tetrame-thylbenzidine as the signal probe. This review article concludes with possible strategies for enhancing and tuning the catalytic activity of CDzymes.
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spelling pubmed-92618112022-07-18 Carbon dots as artificial peroxidases for analytical applications Wei, Shih-Chun Lin, Yang-Wei Chang, Huan-Tsung J Food Drug Anal Review Article Nanozymes have become attractive in analytical and biomedical fields, mainly because of their low cost, long shelf life, and less environmental sensitivity. Particularly, nanozymes formed from nanomaterials having high surface area and rich active sites are interesting since their activities can be tuned through carefully controlling their size, morphology, and surface properties. This review article focuses on preparation of carbon dots (C dots) possessing peroxidase-like activity and their analytical applications. We highlight the important roles of the oxidation states and surface residues of C dots and their nanocomposites with metal, metal oxides, or metal sulfides playing on determining their specificity and sensitivity toward H(2)O(2). Examples of C dot nanozymes (CDzymes) for developing sensitive and selective absorption, fluorescence, and electrochemical sensing systems in the presence of substrates are presented to show their potential in analytical applications. For example, CDzymes couple with glucose oxidase and cholesterol oxidase are specific and sensitive for quantitation of glucose and cholesterol, separately, when using 3,3′,5,5′-tetrame-thylbenzidine as the signal probe. This review article concludes with possible strategies for enhancing and tuning the catalytic activity of CDzymes. Taiwan Food and Drug Administration 2020-12-01 /pmc/articles/PMC9261811/ /pubmed/35696142 http://dx.doi.org/10.38212/2224-6614.1090 Text en © 2020 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Review Article
Wei, Shih-Chun
Lin, Yang-Wei
Chang, Huan-Tsung
Carbon dots as artificial peroxidases for analytical applications
title Carbon dots as artificial peroxidases for analytical applications
title_full Carbon dots as artificial peroxidases for analytical applications
title_fullStr Carbon dots as artificial peroxidases for analytical applications
title_full_unstemmed Carbon dots as artificial peroxidases for analytical applications
title_short Carbon dots as artificial peroxidases for analytical applications
title_sort carbon dots as artificial peroxidases for analytical applications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261811/
https://www.ncbi.nlm.nih.gov/pubmed/35696142
http://dx.doi.org/10.38212/2224-6614.1090
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