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Current and potential applications of simultaneous DSC-FTIR microspectroscopy for pharmaceutical analysis

Quality control (QC) is the most important key issue in the pharmaceutical industry to ensure the quality of drug products. Many analytical instruments and techniques in pharmaceutical analysis are applied to assess the quality and quantity of the drugs. In the current and future trends, a combinati...

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Autor principal: Lin, Shan-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261823/
https://www.ncbi.nlm.nih.gov/pubmed/35696204
http://dx.doi.org/10.38212/2224-6614.3345
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author Lin, Shan-Yang
author_facet Lin, Shan-Yang
author_sort Lin, Shan-Yang
collection PubMed
description Quality control (QC) is the most important key issue in the pharmaceutical industry to ensure the quality of drug products. Many analytical instruments and techniques in pharmaceutical analysis are applied to assess the quality and quantity of the drugs. In the current and future trends, a combination of digitization, automation and hyphenation with high throughput on-line performance will be the topics for the future of pharmaceutical QC. The hyphenated analytical techniques have recently received great attention as unique means to solve complex analytical problems in a short period of time. This review article is an update on the recent potential applications of hyphenated technique developed from the coupling of a rapid separation or induction technique (differential scanning calorimetry; DSC) and an on-line spectroscopic (Fourier transform infrared; FTIR) detection technology to carry out an one-step solid-state analysis in pharmaceutical formulation developments, including (1) intramolecular condensation of pharmaceutical polymers, (2) intramolecular cyclization of drugs and sweetener, (3) polymorphic transformation of drugs and excipients, (4) drug-polymer (excipient) interaction, (5) fast cocrystal screening and formation. This simultaneous DSC-FTIR microspectroscopy can also provide an easy and direct method for one-step screening and qualitative detection of drug stability in real time.
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spelling pubmed-92618232022-07-18 Current and potential applications of simultaneous DSC-FTIR microspectroscopy for pharmaceutical analysis Lin, Shan-Yang J Food Drug Anal Review Article Quality control (QC) is the most important key issue in the pharmaceutical industry to ensure the quality of drug products. Many analytical instruments and techniques in pharmaceutical analysis are applied to assess the quality and quantity of the drugs. In the current and future trends, a combination of digitization, automation and hyphenation with high throughput on-line performance will be the topics for the future of pharmaceutical QC. The hyphenated analytical techniques have recently received great attention as unique means to solve complex analytical problems in a short period of time. This review article is an update on the recent potential applications of hyphenated technique developed from the coupling of a rapid separation or induction technique (differential scanning calorimetry; DSC) and an on-line spectroscopic (Fourier transform infrared; FTIR) detection technology to carry out an one-step solid-state analysis in pharmaceutical formulation developments, including (1) intramolecular condensation of pharmaceutical polymers, (2) intramolecular cyclization of drugs and sweetener, (3) polymorphic transformation of drugs and excipients, (4) drug-polymer (excipient) interaction, (5) fast cocrystal screening and formation. This simultaneous DSC-FTIR microspectroscopy can also provide an easy and direct method for one-step screening and qualitative detection of drug stability in real time. Taiwan Food and Drug Administration 2021-06-15 /pmc/articles/PMC9261823/ /pubmed/35696204 http://dx.doi.org/10.38212/2224-6614.3345 Text en © 2021 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Review Article
Lin, Shan-Yang
Current and potential applications of simultaneous DSC-FTIR microspectroscopy for pharmaceutical analysis
title Current and potential applications of simultaneous DSC-FTIR microspectroscopy for pharmaceutical analysis
title_full Current and potential applications of simultaneous DSC-FTIR microspectroscopy for pharmaceutical analysis
title_fullStr Current and potential applications of simultaneous DSC-FTIR microspectroscopy for pharmaceutical analysis
title_full_unstemmed Current and potential applications of simultaneous DSC-FTIR microspectroscopy for pharmaceutical analysis
title_short Current and potential applications of simultaneous DSC-FTIR microspectroscopy for pharmaceutical analysis
title_sort current and potential applications of simultaneous dsc-ftir microspectroscopy for pharmaceutical analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261823/
https://www.ncbi.nlm.nih.gov/pubmed/35696204
http://dx.doi.org/10.38212/2224-6614.3345
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