A rapid strategy for screening high-efficiency PCSK9 inhibitors from Ginkgo biloba leaves by ligand fishing, HPLC-Q-TOF-MS and interdisciplinary assay

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an attractive target for new cholesterol-lowering drug development. Here, we developed a method integrating ligand fishing, HPLC-Q-TOF-MS and interdisciplinary assay, aiming to explore potential PCSK9 inhibitors from mixtures rapidly and accur...

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Detalles Bibliográficos
Autores principales: Li, Li, Fan, Meng-Lin, Li, Ya-Nan, Huang, Ya-Xuan, Liu, Xiu-Feng, Liu, Ji-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261853/
https://www.ncbi.nlm.nih.gov/pubmed/35696112
http://dx.doi.org/10.38212/2224-6614.1061

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