Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology

BACKGROUND: The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases of COVID-19. However, the molecular mechanisms underlying the release of NETs in COVID-19 remain unclear. OBJECTIVES: We aim to investigate the role...

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Detalles Bibliográficos
Autores principales: Silva, Camila Meirelles S., Wanderley, Carlos Wagner S., Veras, Flavio Protasio, Gonçalves, Augusto Velozo, Lima, Mikhael Haruo Fernandes, Toller-Kawahisa, Juliana Escher, Gomes, Giovanni Freitas, Nascimento, Daniele Carvalho, Monteiro, Valter V. Silva, Paiva, Isadora Marques, Almeida, Cícero José Luíz Ramos, Caetité, Diego Brito, Silva, Juliana Costa, Lopes, Maria Isabel Fernandes, Bonjorno, Letícia Pastorelli, Giannini, Marcela Cavichioli, Amaral, Natalia Brasil, Benatti, Maíra Nilson, Santana, Rodrigo Carvalho, Damasceno, Luis Eduardo Alves, Silva, Bruna Manuella Souza, Schneider, Ayda Henriques, Castro, Icaro Maia Santos, Silva, Juan Carlo Santos, Vasconcelos, Amanda Pereira, Gonçalves, Tiago Tomazini, Batah, Sabrina Setembre, Rodrigues, Tamara Silva, Costa, Victor Ferreira, Pontelli, Marjorie Cornejo, Martins, Ronaldo B., Martins, Timna Varela, Espósito, Danillo Lucas Alves, Cebinelli, Guilherme Cesar Martelossi, da Fonseca, Benedito Antônio Lopes, Leiria, Luiz Osório Silveira, Cunha, Larissa Dias, Arruda, Eurico, Nakaia, Helder I., Fabro, Alexandre Todorovic, Oliveira, Rene D. R., Zamboni, Dario S., Louzada-Junior, Paulo, Cunha, Thiago Mattar, Alves-Filho, José Carlos Farias, Cunha, Fernando Queiroz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261892/
https://www.ncbi.nlm.nih.gov/pubmed/35799268
http://dx.doi.org/10.1186/s13054-022-04062-5

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