Allosteric Modulation of the Main Protease (M(Pro)) of SARS-CoV-2 by Casticin—Insights from Molecular Dynamics Simulations

Inhibition of the main protease (M(pro)) of SARS-CoV-2 has been suggested to be vital in shutting down viral replication in a host. Most efforts aimed at inhibiting M(Pro) activity have been channeled into competitive inhibition at the active site, but this strategy will require a high inhibitor con...

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Detalles Bibliográficos
Autores principales: Mensah, Jehoshaphat Oppong, Ampomah, Gilbert Boadu, Gasu, Edward Ntim, Adomako, Abigail Kusiwaa, Menkah, Elliott Sarpong, Borquaye, Lawrence Sheringham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261893/
http://dx.doi.org/10.1007/s42250-022-00411-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261893/
http://dx.doi.org/10.1007/s42250-022-00411-7

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