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Phage-Related Ribosomal Protease (Prp) of Staphylococcus aureus: In Vitro Michaelis–Menten Kinetics, Screening for Inhibitors, and Crystal Structure of a Covalent Inhibition Product Complex

[Image: see text] Phage-related ribosomal proteases (Prps) are essential for the assembly and maturation of the ribosome in Firmicutes, including the human pathogens Staphylococcus aureus, Streptococcus pneumoniae, and Clostridium difficile. These bacterial proteases cleave off an N-terminal extensi...

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Detalles Bibliográficos
Autores principales:	Hotinger, Julia A., Pendergrass, Heather A., Peterson, Darrell, Wright, H. Tonie, May, Aaron E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261936/ https://www.ncbi.nlm.nih.gov/pubmed/35731716 http://dx.doi.org/10.1021/acs.biochem.2c00010

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